Anti-CBX3/HP1 Gamma, Biotinylated antibody (Internal) {Biotin} (STJ73292) STJ73292-100 上海玉博生物科技有限公司

Anti-CBX3/HP1 Gamma, Biotinylated antibody (Internal) {Biotin} (STJ73292)

简单介绍

Anti-CBX3/HP1 Gamma, Biotinylated antibody (Internal) {Biotin} (STJ73292)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB/IHC
Reactivity:	Human/Mouse/Rat/Dog
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-CBX3/HP1 Gamma, Biotinylated (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-0.1-0.3µg/ml ELISA-antibody detection limit dilution 1:32000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	CBX3
Gene ID:	11335
Uniprot ID:	CBX3_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_009207.2
Specificity:	No cross-reactivity expected with HP1-alpha and HP1-beta. Reported variants represent identical protein: NP_009207.2, NP_057671.2
Immunogen Sequence:	CEAFLNSQKAGKEKD.

Function	Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs).
Protein Name	Chromobox Protein Homolog 3 Hech Heterochromatin Protein 1 Homolog Gamma Hp1 Gamma Modifier 2 Protein
Database Links	Reactome: R-HSA-427389 Reactome: R-HSA-73772 Reactome: R-HSA-8953750
Cellular Localisation	Nucleus Associates With Euchromatin And Is Largely Excluded From Constitutive Heterochromatin May Be Associated With Microtubules And Mitotic Poles During Mitosis (Potential)
Alternative Antibody Names	Anti-Chromobox Protein Homolog 3 antibody Anti-Hech antibody Anti-Heterochromatin Protein 1 Homolog Gamma antibody Anti-Hp1 Gamma antibody Anti-Modifier 2 Protein antibody Anti-CBX3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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