Human SRSF2 (Serine/Arginine Rich Splicing Factor 2) Sandwich ELISA Kit Ready-To-Use (STJE0018728) STJE0018728 上海玉博生物科技有限公司

Human SRSF2 (Serine/Arginine Rich Splicing Factor 2) Sandwich ELISA Kit Ready-To-Use (STJE0018728)

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产品名称：Human SRSF2 (Serine/Arginine Rich Splicing Factor 2) Sandwich ELISA Kit Ready-To-Use (STJE0018728)
产品型号：STJE0018728
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human SRSF2 (Serine/Arginine Rich Splicing Factor 2) Sandwich ELISA Kit Ready-To-Use (STJE0018728)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.054ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This SRSF2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	SRSF2
Gene ID:	6427
Uniprot ID:	SRSF2_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by SRPK2 and this causes its redistribution from the nuclear speckle to nucleoplasm and controls cell fate decision in response to cisplatin treatment. KAT5/TIP60 inhibits its phosphorylation by preventing SRPK2 nuclear translocation. Acetylation on Lys-52 by KAT5/TIP60 promotes its proteasomal degradation. This effect is counterbalanced by HDAC6, which positively controls SRSF2 protein level by deacetylating it and preventing its proteasomal degradation.
Function	Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.
Protein Name	Serine/Arginine-Rich Splicing Factor 2 Protein Pr264 Splicing Component - 35 Kda Splicing Factor Sc35 Sc-35 Splicing Factor - Arginine/Serine-Rich 2
Database Links	Reactome: R-HSA-159236 Reactome: R-HSA-72163 Reactome: R-HSA-72165 Reactome: R-HSA-72187 Reactome: R-HSA-72203 Reactome: R-HSA-73856
Cellular Localisation	Nucleus Nucleoplasm Nucleus Speckle Phosphorylation By Srpk2 Provokes Its Redistribution From The Nuclear Speckle To Nucleoplasm
Alternative ELISA Names	Serine/Arginine-Rich Splicing Factor 2 ELISA kit Protein Pr264 ELISA kit Splicing Component - 35 Kda ELISA kit Splicing Factor Sc35 ELISA kit Sc-35 ELISA kit Splicing Factor - Arginine/Serine-Rich 2 ELISA kit SRSF2 ELISA kit SFRS2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human SRSF2 (Serine/Arginine Rich Splicing Factor 2) Sandwich ELISA Kit Ready-To-Use (STJE0018728)