Human STK11 (Serine/Threonine Kinase 11) Sandwich ELISA Kit Ready-To-Use (STJE0018767) STJE0018767 上海玉博生物科技有限公司

Human STK11 (Serine/Threonine Kinase 11) Sandwich ELISA Kit Ready-To-Use (STJE0018767)

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产品名称：Human STK11 (Serine/Threonine Kinase 11) Sandwich ELISA Kit Ready-To-Use (STJE0018767)
产品型号：STJE0018767
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human STK11 (Serine/Threonine Kinase 11) Sandwich ELISA Kit Ready-To-Use (STJE0018767)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.071ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This STK11 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	STK11
Gene ID:	6794
Uniprot ID:	STK11_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Ubiquitously expressed. Strongest expression in testis and fetal liver.
Post Translational Modifications	Phosphorylated by ATM at Thr-363 following ionizing radiation (IR). Phosphorylation at Ser-428 by RPS6KA1 and/or some PKA is required to inhibit cell growth. Phosphorylation at Ser-428 is also required during neuronal polarization to mediate phosphorylation of BRSK1 and BRSK2. Phosphorylation by PKC/PRKCZ at Ser-399 in isoform 2 promotes metformin (or peroxynitrite)-induced nuclear export of STK11 and activation of AMPK. UV radiation-induced phosphorylation at Thr-363 mediates CDKN1A degradation. Acetylated. Deacetylation at Lys-48 enhances cytoplasmic localization and kinase activity in vitro.
Function	Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53.the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair. Isoform 2: Has a role in spermiogenesis.
Protein Name	Serine/Threonine-Protein Kinase Stk11 Liver Kinase B1 Lkb1 Hlkb1 Renal Carcinoma Antigen Ny-Ren-19
Database Links	Reactome: R-HSA-163680 Reactome: R-HSA-380972 Reactome: R-HSA-6804756 Reactome: R-HSA-9614657
Cellular Localisation	Nucleus Cytoplasm Membrane Mitochondrion A Small Fraction Localizes At Membranes Relocates To The Cytoplasm When Bound To Strad (Strada Or Stradb) And Cab39/Mo25 (Cab39/Mo25alpha Or Cab39l/Mo25beta) Translocates To The Mitochondrion During Apoptosis Pten Promotes Cytoplasmic Localization Isoform 2: Nucleus Predominantly Nuclear But Translocates To The Cytoplasm In Response To Metformin Or Peroxynitrite Treatment
Alternative ELISA Names	Serine/Threonine-Protein Kinase Stk11 ELISA kit Liver Kinase B1 ELISA kit Lkb1 ELISA kit Hlkb1 ELISA kit Renal Carcinoma Antigen Ny-Ren-19 ELISA kit STK11 ELISA kit LKB1 ELISA kit PJS ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human STK11 (Serine/Threonine Kinase 11) Sandwich ELISA Kit Ready-To-Use (STJE0018767)