Anti-CLDN1 antibody (111-211) (STJ11104534) STJ11104534 上海玉博生物科技有限公司

Anti-CLDN1 antibody (111-211) (STJ11104534)

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产品名称：Anti-CLDN1 antibody (111-211) (STJ11104534)
产品型号：STJ11104534
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CLDN1 antibody (111-211) (STJ11104534)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Claudin-1 (111-211) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:1000-1:5000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CLDN1
Gene ID:	9076
Uniprot ID:	CLD1_HUMAN
Immunogen Region:	111-211
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 111-211 of human Claudin 1 (NP_066924.1).
Immunogen Sequence:	DEVQKMRMAVIGGAIFLLAG LAILVATAWYGNRIVQEFYD PMTPVNARYEFGQALFTGWA AASLCLLGGALLCCSCPRKT TSYPTPRPYPKPAPSSGKDY V

Tissue Specificity	Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
Function	Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. (Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. Acts as a receptor for dengue virus.
Protein Name	Claudin-1 Senescence-Associated Epithelial Membrane Protein
Database Links	Reactome: R-HSA-420029
Cellular Localisation	Cell Junction Tight Junction Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Associates With Cd81 And The Cldn1-Cd81 Complex Localizes To The Basolateral Cell Membrane
Alternative Antibody Names	Anti-Claudin-1 antibody Anti-Senescence-Associated Epithelial Membrane Protein antibody Anti-CLDN1 antibody Anti-CLD1 antibody Anti-SEMP1 antibody Anti-UNQ481 antibody Anti-PRO944 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CLDN1 antibody (111-211) (STJ11104534)