您好,欢迎来到仪表展览网!
请登录
免费注册
分享
微信
新浪微博
人人网
QQ空间
开心网
豆瓣
会员服务
进取版
标准版
尊贵版
|
设为首页
|
收藏
|
导航
|
帮助
|
移动端
|
官方微信扫一扫
微信扫一扫
收获行业前沿信息
产品
资讯
请输入产品名称
噪声分析仪
纺织检测仪器
Toc分析仪
PT-303红外测温仪
转矩测试仪
继电保护试验仪
定氮仪
首页
产品
专题
品牌
资料
展会
成功案例
网上展会
词多 效果好 就选易搜宝!
上海玉博生物科技有限公司
新增产品
|
公司简介
注册时间:
2014-10-23
联系人:
电话:
Email:
首页
公司简介
产品目录
公司新闻
技术文章
资料下载
成功案例
人才招聘
荣誉证书
联系我们
产品目录
A类
absolute antibody
a
a & g pharmaceuticals官网
a.g scientific
Aalto
Aalto Scientific
aaltobioreagents
aaltoscientific
aat
aat bioquest
B类
Bacharach Inc
Bachem
backman coulter
badrilla
Bangs
bangs laboratories
bangslab
bangslabs
Barnant Company
Barnstead International
C类
CASMASCI
C
Cadence Science
caisson labs
Calbiochem
CalBioreagents
calbiotech
California Bioscience
california bioscience2
california peptide research
D类
Dade-Behring
daiichi fine chemical
Dako
Davis Instruments
DB Biotech
dbbiotech
DBS
DCS
De Novo Software
deciphergen
E类
EpiCypher
eagle
Eagle BioSciences
Eagle Manufacturing
Eagle Manufacturing Company
Eagle Manufacturing Company/Eagle Mfg. Company
Eagle Thermoplastics Inc.
EarthOx
eastcoast
Eastwood Manufacturing Co.
F类
FabGennix
Falcon Safety
Falcon Safety Products Inc.
Fawcett Company Inc.
FD NEURO TECHNOLOGIES
FD NeuroTechnologies
fd neurotechnologies2
FDNeuroo
fdneurotech
fdneurotech/fd neurotechnologies/FD NEURO TECHNOLOGIES
G类
G C Fuller
GALAB technologies
gallusimmunotech
Gast Manufacturing, Inc.
Gawet Marble
GBD
gbi
gbi-inc
gbiosciences
GBP
H类
Haematologic Technologies
Haematologic Technologies Inc
hamilton
Hampton
Handyem
HANNA
hawksley
HBM
HBT
Hellma
I类
Isosep
IBA
IBA-go
ibexpharma
Ibidi
IBL
IBL-America
ibtsystems
ICLLab
Icosagen
J类
Jackson
Jackson ImmunoResearch
JCRB
jena bioscience
jenabioscience
JPC
JRS Medical
K类
Kalen Biomedical
Kamiya
kapabiosystems
katchem
katena
kentscientific
kerafast
KERRY
Kingfisher Biotech
Kollodis BioSciences
L类
Labfrontier
Labnet
labscientific
Labvision
Lancaster
larodan
LaysanBio
LC Laboratories
lclabs
LDN
M类
moradec
molzym
magsphere
Mabtech
Macherey-Nagel
macrocyclics
Macs Miltenyi
Magen
MagnaMedics
maravai lifesciences
N类
nanocomposix
Nexcelom Bioscience
nabertherm
Nalgene
Nano
NanoBac
NanoLight Technologies
nanoprobes
nanoscience
NANOSOFT POLYMERS
O类
Ocean NanoTech
OEM Concept
OET
ohaus
ohio valley specialty
oligoengine
Omega试剂盒
omicron Biochemicals
omicronbio
Omni International
P类
panagene
Polymer source
phosphorex
Pall
PANATecs
Panomics
panpath
Parafilm
PBL InterferonSource
Pel-Freez
Q类
QAbio
QBG
QED bioscience
QEDbioscience
Qiagen
Quansys Biosciences
Quanta Biosciences
quantabiodesign
quickzyme
Quidel
R类
rossix
R&D
Rainin
RayBiotech
RB
RBC bioscience
R-biopharm
RECI
Relia Tech
RELIATech
S类
Spirochrome
S&S
SABiosciences
salimetrics
Sanquin
Santa Cruz
sanyo
Sartorius
SBA
SBI
T类
terrace biotech
taiclone
Takara
TaqMan
targetingsystems
TCI
Techne
Technoclone
Tecrea
Ted Pella
U类
UBPBIO
U-Cytech
UmanDiagnostics
UnionBiometrica
unitedchem
Upstate
Us biological
Usb
usbio
Usbiological
V类
valasciences
Valley Biomedical
Varian
Vector
Vector Laboratories
Vectorlabs
verichem
veridex
viagenbiotech
ViennaLab
W类
Wako
warner
waters
werner bioAgents
whatman
WHO
Wieslab
worthington
wpiinc
WSU Monoclonal Antibody Center
X类
Xcessbio
X-Rite
Y类
Yakult
yesbiotech
YSL
Z类
zedira
ZENOAQ
ZeptoMetrix
zyagen
zyagen Laboratories
Zymed
Zymo Research
zytovision
5 prime
3-M Company
3hbiomedical
3h biomedical
3dhistech
3D Matrix
3D Biomatrix
胎牛血清
85ml离心管
密理博
5prime
4adi
4rtilab
实验仪器
实验试剂
细胞分离液
培养基
转染试剂
外泌体提取试剂盒
硫酸钠葡聚糖
胶原酶
实验耗材
封板膜
细胞计数板
测试
当前位置:
首页
>>>
产品目录
>>>
S类
>>> 
ST john's laboratory
仪表展览网
>>>
展馆展区
>>>
Anti-CCAR2/DBC1 antibody (842-855) (STJ73096)
>
Anti-CCAR2/DBC1 antibody (842-855) (STJ73096)
产品资料
Anti-CCAR2/DBC1 antibody (842-855) (STJ73096)
如果您对该产品感兴趣的话,可以
产品名称:
Anti-CCAR2/DBC1 antibody (842-855) (STJ73096)
产品型号:
STJ73096-100
产品展商:
ST john's laboratory
产品文档:
无相关文档
简单介绍
Anti-CCAR2/DBC1 antibody (842-855) (STJ73096)
产品描述
Host:
Goat
Applications:
Pep-ELISA/WB
Reactivity:
Human/Mouse/Rat/Dog/Pig/Cow
Note:
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:
Goat polyclonal antibody anti-CCAR2/DBC1 (842-855) is suitable for use in ELISA and Western Blot research applications.
Clonality:
Polyclonal
Conjugation:
Unconjugated
Isotype:
IgG
Formulation:
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:
0.5 mg/mL
Dilution Range:
ELISA-antibody detection limit dilution 1:64000.
Storage Instruction:
Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol:
CCAR2
Gene ID:
57805
Uniprot ID:
CCAR2_HUMAN
Immunogen Region:
842-855
Accession Number:
NP_066997.3
Immunogen Sequence:
ESHNRFSATEVTNK
Post Translational Modifications
ATM/ATR-mediated phosphorylation at Thr-454 upon DNA damage promotes binding to SIRT1. Phosphorylation at Thr-454 promotes its sumoylation by switching the binding partner of CCAR2 from SENP1 to PIAS3. Acetylation at Lys-112 and Lys-215 by KAT8 prevents inhibitory binding to SIRT1 and increases its deacetylase activity. Genotoxic stress induces its sumoylation and sumoylation promotes the SIRT1-CCAR2 interaction which in turn inhibits SIRT1-mediated deacetylation of p53/TP53. Sumoylation leads to transcriptional activation of p53/TP53 by sequestering SIRT1 from p53/TP53. Desumoylated by SENP1.
Function
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. Mediates ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation. Represses the ligand-dependent transcriptional activation function of ESR2. Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1. Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization. Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway. Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3. Plays an important role in tumor suppression through p53/TP53 regulation.stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2. Represses the transcriptional activator activity of BRCA1. Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro.
Protein Name
Cell Cycle And Apoptosis Regulator Protein 2
Cell Division Cycle And Apoptosis Regulator Protein 2
Dbird Complex Subunit Kiaa1967
Deleted In Breast Cancer Gene 1 Protein
Dbc-1
Dbc.1
Net35
P30 Dbc
Database Links
Reactome: R-HSA-3371453
Cellular Localisation
Nucleus
Cytoplasm
Cytoskeleton
Spindle
Recruited To Chromatin
Post-Uv Irradiation
Sequestered To The Cytoplasm In The Presence Of Mcc
Translocated To The Cytoplasm During Uv-Induced Apoptosis
Alternative Antibody Names
Anti-Cell Cycle And Apoptosis Regulator Protein 2 antibody
Anti-Cell Division Cycle And Apoptosis Regulator Protein 2 antibody
Anti-Dbird Complex Subunit Kiaa1967 antibody
Anti-Deleted In Breast Cancer Gene 1 Protein antibody
Anti-Dbc-1 antibody
Anti-Dbc.1 antibody
Anti-Net35 antibody
Anti-P30 Dbc antibody
Anti-CCAR2 antibody
Anti-DBC1 antibody
Anti-KIAA1967 antibody
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
产品留言
标题
联系人
联系电话
内容
验证码
点击换一张
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!
温馨提示:为规避购买风险,建议您在购买前务必确认供应商资质与产品质量。
免责申明:以上内容为注册会员自行发布,若信息的真实性、合法性存在争议,平台将会监督协助处理,
欢迎举报
产品留言
标题
内容
联系人
联系电话
电子邮件
公司名称
联系地址
验证码
点击换一张
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!
相关产品
Anti-Pan myristoylation antibody STJ98665
ST john's laboratory中国代理商2020
Anti-14-3-3 beta/Theta antibody (1-100) [S1MR] (STJ11103651) STJ11103651
Anti-14-3-3 Beta/Zeta antibody (151-200 aa) (STJ91368) STJ91368
Anti-14-3-3 sigma/Stratifin antibody (Internal) (STJ70838) STJ70838-100
Anti-14-3-3 sigma/Stratifin, Biotinylated antibody (Internal) {Biotin} (STJ73293) STJ73293-100
Anti-14-3-3 tau/YWHAQ antibody (Internal) (STJ71355) STJ71355-100
Anti-2 NA-O-methyl-2mA antibody (STJ11100889) STJ11100889
Anti-2 NA-O-methylcytidine/Cm antibody (STJ11103959) STJ11103959
Anti-2 NA-O-methylcytidine/Cm antibody [S4061RM] (STJ11104061) STJ11104061
Anti-2019-covid N protein antibody (STJA0010175) STJA0010175
Anti-2019-covid N protein antibody (STJA0010176) STJA0010176
Anti-2019-nCoV antibody [S0MR] (STJ11101210) STJ11101210
Anti-2019-nCoV antibody [S1MR] (STJ11101211) STJ11101211
Anti-25-OH-VD antibody [S5669RM] (STJ11105669) STJ11105669
若网站内容侵犯到您的权益,请通过网站上的联系方式及时联系我们修改或删除
沪公网安备 31011002002624号