Human SYTL2 (Synaptotagmin Like Protein 2) Sandwich ELISA Kit (STJE0012417) STJE0012417 上海玉博生物科技有限公司

Human SYTL2 (Synaptotagmin Like Protein 2) Sandwich ELISA Kit (STJE0012417)

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产品名称：Human SYTL2 (Synaptotagmin Like Protein 2) Sandwich ELISA Kit (STJE0012417)
产品型号：STJE0012417
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human SYTL2 (Synaptotagmin Like Protein 2) Sandwich ELISA Kit (STJE0012417)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.113ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This SYTL2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	SYTL2
Gene ID:	54843
Uniprot ID:	SYTL2_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells.
Post Translational Modifications	Isoform 1 is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A.
Function	Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.
Protein Name	Synaptotagmin-Like Protein 2 Breast Cancer-Associated Antigen Sga-72m Exophilin-4
Database Links
Cellular Localisation	Isoform 1: Cytoplasm Cell Membrane Recruited On Vesicular Structures In Cytotoxic T-Lymphocytes (Ctl) By Rab27a Isoform 4: Cell Membrane In The Pancreatic Alpha Cells Distributed In Both Peripheral And Anterior Regions Localizes On The Glucagon Granules In The Cell Periphery
Alternative ELISA Names	Synaptotagmin-Like Protein 2 ELISA kit Breast Cancer-Associated Antigen Sga-72m ELISA kit Exophilin-4 ELISA kit SYTL2 ELISA kit KIAA1597 ELISA kit SGA72M ELISA kit SLP2 ELISA kit SLP2A ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human SYTL2 (Synaptotagmin Like Protein 2) Sandwich ELISA Kit (STJE0012417)