Anti-CLDN7 antibody (29-211) (STJ23163) STJ23163 上海玉博生物科技有限公司

Anti-CLDN7 antibody (29-211) (STJ23163)

简单介绍

Anti-CLDN7 antibody (29-211) (STJ23163)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CLDN7 (29-211) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IF/ICC 1:100-1:500
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CLDN7
Gene ID:	1366
Uniprot ID:	CLD7_HUMAN
Immunogen Region:	29-211
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 29-211 of human CLDN7 (NP_001298.3).
Immunogen Sequence:	QWQMSSYAGDNIITAQAMYK GLWMDCVTQSTGMMSCKMYD SVLALSAALQATRALMVVSL VLGFLAMFVATMGMKCTRCG GDDKVKKARIAMGGGIIFIV AGLAALVACSWYGHQIVTDF YNPLIPTNIKYEFGPAIFIG WAGSALVILGGALLSCSCPG NESKAGYRVPRSYPKSNSSK EYV

Tissue Specificity	Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
Post Translational Modifications	Phosphorylated.
Function	Plays a major role in tight junction-specific obliteration of the intercellular space.
Protein Name	Claudin-7 Cldn-7
Database Links	Reactome: R-HSA-420029
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Cell Junction Tight Junction Co-Localizes With Epcam At The Basolateral Cell Membrane And Tight Junction
Alternative Antibody Names	Anti-Claudin-7 antibody Anti-Cldn-7 antibody Anti-CLDN7 antibody Anti-CEPTRL2 antibody Anti-CPETRL2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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