Anti-Cleaved-ACAN-D369 antibody (320-369 aa) (STJ90041) STJ90041 上海玉博生物科技有限公司

Anti-Cleaved-ACAN-D369 antibody (320-369 aa) (STJ90041)

简单介绍

Anti-Cleaved-ACAN-D369 antibody (320-369 aa) (STJ90041)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cleaved-Aggrecan core protein-D369 (320-369 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ACAN
Gene ID:	176
Uniprot ID:	PGCA_HUMAN
Immunogen Region:	320-369 aa
Specificity:	Cleaved-Aggrecan (D369) Polyclonal Antibody detects endogenous levels of fragment of activated Aggrecan protein resulting from cleavage adjacent to D369.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human Aggrecan at the amino acid range 320-369

Post Translational Modifications	Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.
Function	This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
Protein Name	Aggrecan Core Protein Cartilage-Specific Proteoglycan Core Protein Cspcp Chondroitin Sulfate Proteoglycan Core Protein 1 Chondroitin Sulfate Proteoglycan 1 Cleaved Into - Aggrecan Core Protein 2
Database Links	Reactome: R-HSA-1474228 Reactome: R-HSA-2022854 Reactome: R-HSA-2022857 Reactome: R-HSA-3000178 Reactome: R-HSA-3656225 Reactome: R-HSA-3656243 Reactome: R-HSA-3656244
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix
Alternative Antibody Names	Anti-Aggrecan Core Protein antibody Anti-Cartilage-Specific Proteoglycan Core Protein antibody Anti-Cspcp antibody Anti-Chondroitin Sulfate Proteoglycan Core Protein 1 antibody Anti-Chondroitin Sulfate Proteoglycan 1 Cleaved Into - Aggrecan Core Protein 2 antibody Anti-ACAN antibody Anti-AGC1 antibody Anti-CSPG1 antibody Anti-MSK16 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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