Anti-Cleaved-ADGRE2-Leu517 antibody (517-518) (STJA0005855) STJA0005855 上海玉博生物科技有限公司

Anti-Cleaved-ADGRE2-Leu517 antibody (517-518) (STJA0005855)

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产品名称：Anti-Cleaved-ADGRE2-Leu517 antibody (517-518) (STJA0005855)
产品型号：STJA0005855
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Cleaved-ADGRE2-Leu517 antibody (517-518) (STJA0005855)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cleaved-Adhesion G protein-coupled receptor E2-Leu517 (517-518) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:1000-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ADGRE2
Gene ID:	30817
Uniprot ID:	AGRE2_HUMAN
Immunogen Region:	517-518
Specificity:	This antibody detects endogenous levels of Human EMR2 (Cleaved-Leu517, protein was cleaved amino acid sequence between 517-518 )
Immunogen:	Synthesized peptide derived from human EMR2 (Cleaved-Leu517)

Tissue Specificity	Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested. High expression in mast cells.
Post Translational Modifications	Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit.
Function	Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation.
Protein Name	Adhesion G Protein-Coupled Receptor E2 Egf-Like Module Receptor 2 Egf-Like Module-Containing Mucin-Like Hormone Receptor-Like 2 Cd Antigen Cd312
Database Links	Reactome: R-HSA-373080
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Cell Projection Ruffle Membrane Localized At The Leading Edge Of Migrating Cells
Alternative Antibody Names	Anti-Adhesion G Protein-Coupled Receptor E2 antibody Anti-Egf-Like Module Receptor 2 antibody Anti-Egf-Like Module-Containing Mucin-Like Hormone Receptor-Like 2 antibody Anti-Cd Antigen Cd312 antibody Anti-ADGRE2 antibody Anti-EMR2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Cleaved-ADGRE2-Leu517 antibody (517-518) (STJA0005855)