Human TDG (Thymine DNA Glycosylase) Sandwich ELISA Kit Ready-To-Use (STJE0018849) STJE0018849 上海玉博生物科技有限公司

Human TDG (Thymine DNA Glycosylase) Sandwich ELISA Kit Ready-To-Use (STJE0018849)

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产品名称：Human TDG (Thymine DNA Glycosylase) Sandwich ELISA Kit Ready-To-Use (STJE0018849)
产品型号：STJE0018849
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human TDG (Thymine DNA Glycosylase) Sandwich ELISA Kit Ready-To-Use (STJE0018849)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.038ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This TDG Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	TDG
Gene ID:	6996
Uniprot ID:	TDG_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Sumoylation on Lys-330 by either SUMO1 or SUMO2 induces dissociation of the product DNA.
Function	DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.
Protein Name	G/T Mismatch-Specific Thymine Dna Glycosylase Thymine-Dna Glycosylase Htdg
Database Links	Reactome: R-HSA-110328 Reactome: R-HSA-110329 Reactome: R-HSA-110357 Reactome: R-HSA-3108214 Reactome: R-HSA-5221030
Cellular Localisation	Nucleus
Alternative ELISA Names	G/T Mismatch-Specific Thymine Dna Glycosylase ELISA kit Thymine-Dna Glycosylase ELISA kit Htdg ELISA kit TDG ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human TDG (Thymine DNA Glycosylase) Sandwich ELISA Kit Ready-To-Use (STJE0018849)