Anti-Cleaved-CASP10-Val220 antibody (STJ193237) STJ193237 上海玉博生物科技有限公司

Anti-Cleaved-CASP10-Val220 antibody (STJ193237)

简单介绍

Anti-Cleaved-CASP10-Val220 antibody (STJ193237)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cleaved-Caspase-10-Val220 is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 ELISA-Pep 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CASP10
Gene ID:	843
Uniprot ID:	CASPA_HUMAN
Specificity:	This antibody detects endogenous levels of human Caspase 10 (p23/17, Cleaved-Val220)
Immunogen:	Synthesized peptide derived from the human Caspase 10 (p23/17, Cleaved-Val220)

Post Translational Modifications	Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-\|-AMC and Asp-Glu-Val-Asp-\|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Isoform C is proteolytically inactive.
Protein Name	Caspase-10 Casp-10 Apoptotic Protease Mch-4 Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2 Flice2 Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12
Database Links	Reactome: R-HSA-6803207 Reactome: R-HSA-75157 Reactome: R-HSA-75158 Reactome: R-HSA-933543
Alternative Antibody Names	Anti-Caspase-10 antibody Anti-Casp-10 antibody Anti-Apoptotic Protease Mch-4 antibody Anti-Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2 antibody Anti-Flice2 antibody Anti-Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12 antibody Anti-CASP10 antibody Anti-MCH4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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