Anti-Cleaved-CASP3-D175 antibody (126-175 aa) (STJ90005) STJ90005 上海玉博生物科技有限公司

Anti-Cleaved-CASP3-D175 antibody (126-175 aa) (STJ90005)

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产品名称：Anti-Cleaved-CASP3-D175 antibody (126-175 aa) (STJ90005)
产品型号：STJ90005
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Cleaved-CASP3-D175 antibody (126-175 aa) (STJ90005)

产品描述

Host:	Rabbit
Applications:	WB/IF/IHC/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cleaved-Caspase-3-D175 (126-175 aa) is suitable for use in Western Blot, Immunofluorescence, Immunohistochemistry and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 IHC-P 1:50-300 IF 1:50-300
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CASP3
Gene ID:	836
Uniprot ID:	CASP3_HUMAN
Immunogen Region:	126-175 aa
Specificity:	Cleaved-Caspase-3 p17 (D175) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-3 p17 protein resulting from cleavage adjacent to D175.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human Caspase 3 at the amino acid range 126-175

Post Translational Modifications	Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa. S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol. (Microbial infection) ADP-riboxanation by C.violaceum CopC blocks CASP3 processing, preventing CASP3 activation and ability to recognize and cleave substrates.
Function	Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis. Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction. Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface.
Protein Name	Caspase-3 Casp-3 Apopain Cysteine Protease Cpp32 Cpp-32 Protein Yama Srebp Cleavage Activity 1 Sca-1 Cleaved Into - Caspase-3 Subunit P17 - Caspase-3 Subunit P12
Database Links	Reactome: R-HSA-111459 Reactome: R-HSA-111463 Reactome: R-HSA-111464 Reactome: R-HSA-111465 Reactome: R-HSA-111469 Reactome: R-HSA-140342 Reactome: R-HSA-1474228 Reactome: R-HSA-2028269 Reactome: R-HSA-205025 Reactome: R-HSA-211736 Reactome: R-HSA-264870 Reactome: R-HSA-351906 Reactome: R-HSA-418889 Reactome: R-HSA-449836 Reactome: R-HSA-5620971
Cellular Localisation	Cytoplasm
Alternative Antibody Names	Anti-Caspase-3 antibody Anti-Casp-3 antibody Anti-Apopain antibody Anti-Cysteine Protease Cpp32 antibody Anti-Cpp-32 antibody Anti-Protein Yama antibody Anti-Srebp Cleavage Activity 1 antibody Anti-Sca-1 Cleaved Into - Caspase-3 Subunit P17 - Caspase-3 Subunit P12 antibody Anti-CASP3 antibody Anti-CPP32 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Cleaved-CASP3-D175 antibody (126-175 aa) (STJ90005)