Anti-Cleaved-CASP5-S331 antibody (312-361 aa) (STJ90029) STJ90029 上海玉博生物科技有限公司

Anti-Cleaved-CASP5-S331 antibody (312-361 aa) (STJ90029)

简单介绍

Anti-Cleaved-CASP5-S331 antibody (312-361 aa) (STJ90029)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cleaved-Caspase-5-III-S331 (312-361 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 ELISA 1:20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CASP5
Gene ID:	838
Uniprot ID:	CASP5_HUMAN
Immunogen Region:	312-361 aa
Specificity:	Cleaved-Caspase-5 p10 (S331) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-5 p10 protein resulting from cleavage adjacent to S331.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human Caspase 5 at the amino acid range 312-361

Post Translational Modifications	The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
Function	Thiol protease that acts as a mediator of programmed cell death. Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation.
Protein Name	Caspase-5 Casp-5 Ice(Rel-Iii Protease Ich-3 Protease Ty Cleaved Into - Caspase-5 Subunit P20 - Caspase-5 Subunit P10
Database Links	Reactome: R-HSA-5620971
Alternative Antibody Names	Anti-Caspase-5 antibody Anti-Casp-5 antibody Anti-Ice(Rel-Iii antibody Anti-Protease Ich-3 antibody Anti-Protease Ty Cleaved Into - Caspase-5 Subunit P20 - Caspase-5 Subunit P10 antibody Anti-CASP5 antibody Anti-ICH3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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