Anti-Cleaved-CASP9-D330 antibody (281-330 aa) (STJ90012) STJ90012 上海玉博生物科技有限公司

Anti-Cleaved-CASP9-D330 antibody (281-330 aa) (STJ90012)

如果您对该产品感兴趣的话，可以
产品名称：Anti-Cleaved-CASP9-D330 antibody (281-330 aa) (STJ90012)
产品型号：STJ90012
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Cleaved-CASP9-D330 antibody (281-330 aa) (STJ90012)

产品描述

Host:	Rabbit
Applications:	IF/WB/IHC/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cleaved-Caspase-9-D330 (281-330 aa) is suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	IF 1:50-200 WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CASP9
Gene ID:	842
Uniprot ID:	CASP9_HUMAN
Immunogen Region:	281-330 aa
Specificity:	Cleaved-Caspase-9 p10 (D330) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-9 p10 protein resulting from cleavage adjacent to D330.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human Caspase 9 at the amino acid range 281-330

Post Translational Modifications	Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events. Phosphorylated at Thr-125 by MAPK1/ERK2. Phosphorylation at Thr-125 is sufficient to block caspase-9 processing and subsequent caspase-3 activation. Phosphorylation on Tyr-153 by ABL1/c-Abl.occurs in the response of cells to DNA damage. (Microbial infection) ADP-riboxanation by C.violaceum CopC blocks CASP9 processing, preventing CASP9 activation and ability to mediate intrinsic apoptosis.
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2: Lacks activity is an dominant-negative inhibitor of caspase-9.
Protein Name	Caspase-9 Casp-9 Apoptotic Protease Mch-6 Apoptotic Protease-Activating Factor 3 Apaf-3 Ice-Like Apoptotic Protease 6 Ice-Lap6 Cleaved Into - Caspase-9 Subunit P35 - Caspase-9 Subunit P10
Database Links	Reactome: R-HSA-111458 Reactome: R-HSA-111459 Reactome: R-HSA-111463 Reactome: R-HSA-111464 Reactome: R-HSA-168638 Reactome: R-HSA-198323 Reactome: R-HSA-418889 Reactome: R-HSA-5674400 Reactome: R-HSA-9627069
Alternative Antibody Names	Anti-Caspase-9 antibody Anti-Casp-9 antibody Anti-Apoptotic Protease Mch-6 antibody Anti-Apoptotic Protease-Activating Factor 3 antibody Anti-Apaf-3 antibody Anti-Ice-Like Apoptotic Protease 6 antibody Anti-Ice-Lap6 Cleaved Into - Caspase-9 Subunit P35 - Caspase-9 Subunit P10 antibody Anti-CASP9 antibody Anti-MCH6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Anti-Cleaved-CASP9-D330 antibody (281-330 aa) (STJ90012)