Anti-Cleaved-COL18A1-His1572 antibody (1571-1572) (STJA0005845) STJA0005845 上海玉博生物科技有限公司

Anti-Cleaved-COL18A1-His1572 antibody (1571-1572) (STJA0005845)

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产品名称：Anti-Cleaved-COL18A1-His1572 antibody (1571-1572) (STJA0005845)
产品型号：STJA0005845
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Cleaved-COL18A1-His1572 antibody (1571-1572) (STJA0005845)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cleaved-Collagen alpha-1XVIII chain-His1572 (1571-1572) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:1000-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	COL18A1
Gene ID:	80781
Uniprot ID:	COIA1_HUMAN
Immunogen Region:	1571-1572
Specificity:	This antibody detects endogenous levels of Human, Mouse Collagen XVIII Alpha 1 (Cleaved-His1572, protein was cleaved amino acid sequence between 1571-1572 )
Immunogen:	Synthesized peptide derived from human Collagen XVIII Alpha 1 (Cleaved-His1572)

Tissue Specificity	Detected in placenta (at protein level). Present in multiple organs with highest levels in liver, lung and kidney.
Post Translational Modifications	Prolines at the third position of the tripeptide repeating unit (G-X-Y) of the triple-helical regions are hydroxylated. Circulating endostatins are found as sialoglycoprotein and asialoglycoprotein structures. Undergoes proteolytic processing by CTSL/cathepsin-L and elastase-like proteases to generate both non-collagenous domain 1 trimers and endostatin monomers. In tissue extracts (brain, skeletal muscle, heart, kidney, testis and liver) predominantly bands of approximately 38 kDa are detected.recombinant non-collagenous domain 1 shows similar mobility. In vitro, several proteolytic cleavage sites in the non-collagenous domain 1 hinge region generating different endostatin-like peptides are reported.
Function	Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Non-collagenous domain 1: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells.the function requires homotrimerization and implicates MAPK signaling. Endostatin: Potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5. May negatively regulate the activity of homotrimeric non-collagenous domain 1.
Protein Name	Collagen Alpha-1(Xviii Chain Cleaved Into - Endostatin - Non-Collagenous Domain 1 Nc1
Database Links	Reactome: R-HSA-1442490 Reactome: R-HSA-1592389 Reactome: R-HSA-1650814 Reactome: R-HSA-2022090 Reactome: R-HSA-216083 Reactome: R-HSA-3000157 Reactome: R-HSA-8948216
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix Basement Membrane Non-Collagenous Domain 1: Secreted Endostatin: Secreted
Alternative Antibody Names	Anti-Collagen Alpha-1(Xviii Chain Cleaved Into - Endostatin - Non-Collagenous Domain 1 antibody Anti-Nc1 antibody Anti-COL18A1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Cleaved-COL18A1-His1572 antibody (1571-1572) (STJA0005845)