Anti-Cleaved-COL2A1-Ala1241 antibody (1241-1242) (STJA0005840) STJA0005840 上海玉博生物科技有限公司

Anti-Cleaved-COL2A1-Ala1241 antibody (1241-1242) (STJA0005840)

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产品名称：Anti-Cleaved-COL2A1-Ala1241 antibody (1241-1242) (STJA0005840)
产品型号：STJA0005840
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Cleaved-COL2A1-Ala1241 antibody (1241-1242) (STJA0005840)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cleaved-Collagen alpha-1II chain-Ala1241 (1241-1242) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:1000-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	COL2A1
Gene ID:	1280
Uniprot ID:	CO2A1_HUMAN
Immunogen Region:	1241-1242
Specificity:	This antibody detects endogenous levels of Human, Mouse, Rat Collagen II Alpha 1 (Cleaved-Ala1241, protein was cleaved amino acid sequence between 1241-1242 )
Immunogen:	Synthesized peptide derived from human Collagen II Alpha 1 (Cleaved-Ala1241)

Tissue Specificity	Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte.
Post Translational Modifications	The N-telopeptide is covalently linked to the helical COL2 region of alpha 1(IX), alpha 2(IX) and alpha 3(IX) chain. The C-telopeptide is covalently linked to an another site in the helical region of alpha 3(IX) COL2. Contains mostly 4-hydroxyproline. Prolines at the third position of the tripeptide repeating unit (G-X-P) are 4-hydroxylated in some or all of the chains. Contains 3-hydroxyproline at a few sites. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4-hydroxyproline. Lysine residues at the third position of the tripeptide repeating unit (G-X-Y) are 5-hydroxylated in some or all of the chains. O-glycosylated on hydroxylated lysine residues. The O-linked glycan consists of a Glc-Gal disaccharide.
Function	Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
Protein Name	Collagen Alpha-1(Ii Chain Alpha-1 Type Ii Collagen Cleaved Into - Collagen Alpha-1(Ii Chain - Chondrocalcin
Database Links	Reactome: R-HSA-1442490 Reactome: R-HSA-1474244 Reactome: R-HSA-1650814 Reactome: R-HSA-186797 Reactome: R-HSA-198933 Reactome: R-HSA-2022090 Reactome: R-HSA-216083 Reactome: R-HSA-3000171 Reactome: R-HSA-3000178 Reactome: R-HSA-419037 Reactome: R-HSA-8874081 Reactome: R-HSA-8948216
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix
Alternative Antibody Names	Anti-Collagen Alpha-1(Ii Chain antibody Anti-Alpha-1 Type Ii Collagen Cleaved Into - Collagen Alpha-1(Ii Chain - Chondrocalcin antibody Anti-COL2A1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Cleaved-COL2A1-Ala1241 antibody (1241-1242) (STJA0005840)