Anti-Cleaved-COL4A2-Ser1485 antibody (1485-1486) (STJA0005846) STJA0005846 上海玉博生物科技有限公司

Anti-Cleaved-COL4A2-Ser1485 antibody (1485-1486) (STJA0005846)

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产品名称：Anti-Cleaved-COL4A2-Ser1485 antibody (1485-1486) (STJA0005846)
产品型号：STJA0005846
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Cleaved-COL4A2-Ser1485 antibody (1485-1486) (STJA0005846)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cleaved-Collagen alpha-2IV chain-Ser1485 (1485-1486) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:1000-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	COL4A2
Gene ID:	1284
Uniprot ID:	CO4A2_HUMAN
Immunogen Region:	1485-1486
Specificity:	This antibody detects endogenous levels of Human, Mouse Collagen IV Alpha 2 (Cleaved-Ser1485, protein was cleaved amino acid sequence between 1485-1486 )
Immunogen:	Synthesized peptide derived from human Collagen IV Alpha 2 (Cleaved-Ser1485)

Post Translational Modifications	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues. Proteolytic processing produces the C-terminal NC1 peptide, canstatin.
Function	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
Protein Name	Collagen Alpha-2(Iv Chain Cleaved Into - Canstatin
Database Links	Reactome: R-HSA-1442490 Reactome: R-HSA-1474244 Reactome: R-HSA-1650814 Reactome: R-HSA-186797 Reactome: R-HSA-2022090 Reactome: R-HSA-216083 Reactome: R-HSA-2214320 Reactome: R-HSA-2243919 Reactome: R-HSA-3000157 Reactome: R-HSA-3000171 Reactome: R-HSA-3000178 Reactome: R-HSA-3000480 Reactome: R-HSA-419037 Reactome: R-HSA-8948216
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix Basement Membrane
Alternative Antibody Names	Anti-Collagen Alpha-2(Iv Chain Cleaved Into - Canstatin antibody Anti-COL4A2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Cleaved-COL4A2-Ser1485 antibody (1485-1486) (STJA0005846)