Anti-Cleaved-COL4A3-P1426 antibody (1407-1456 aa) (STJ90077) STJ90077 上海玉博生物科技有限公司

Anti-Cleaved-COL4A3-P1426 antibody (1407-1456 aa) (STJ90077)

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产品名称：Anti-Cleaved-COL4A3-P1426 antibody (1407-1456 aa) (STJ90077)
产品型号：STJ90077
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Cleaved-COL4A3-P1426 antibody (1407-1456 aa) (STJ90077)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Monkey
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cleaved-Collagen alpha-3IV chain-P1426 (1407-1456 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 ELISA 1:40000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	COL4A3
Gene ID:	1285
Uniprot ID:	CO4A3_HUMAN
Immunogen Region:	1407-1456 aa
Specificity:	Cleaved-Tumstatin (P1426) Polyclonal Antibody detects endogenous levels of fragment of activated Tumstatin protein resulting from cleavage adjacent to P1426.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human Collagen IV alpha3 at the amino acid range 1407-1456

Post Translational Modifications	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Isoform 2 contains an additional N-linked glycosylation site. Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues. Phosphorylated. Thought to be phosphorylated by CERT, but CERT does not have kinase activity.
Function	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity.these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms.
Protein Name	Collagen Alpha-3(Iv Chain Goodpasture Antigen Cleaved Into - Tumstatin
Database Links	Reactome: R-HSA-1442490 Reactome: R-HSA-1474244 Reactome: R-HSA-1650814 Reactome: R-HSA-186797 Reactome: R-HSA-2022090 Reactome: R-HSA-216083 Reactome: R-HSA-2214320 Reactome: R-HSA-2243919 Reactome: R-HSA-3000157 Reactome: R-HSA-3000171 Reactome: R-HSA-3000178 Reactome: R-HSA-419037 Reactome: R-HSA-8948216
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix Basement Membrane Colocalizes With Col4a4 And Col4a5 In Gbm Tubular Basement Membrane (Tbm) And Synaptic Basal Lamina (Bl)
Alternative Antibody Names	Anti-Collagen Alpha-3(Iv Chain antibody Anti-Goodpasture Antigen Cleaved Into - Tumstatin antibody Anti-COL4A3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Cleaved-COL4A3-P1426 antibody (1407-1456 aa) (STJ90077)