Human TFR (Transferrin Receptor) Sandwich ELISA Kit Ready-To-Use (STJE0018881) STJE0018881 上海玉博生物科技有限公司

Human TFR (Transferrin Receptor) Sandwich ELISA Kit Ready-To-Use (STJE0018881)

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产品名称：Human TFR (Transferrin Receptor) Sandwich ELISA Kit Ready-To-Use (STJE0018881)
产品型号：STJE0018881
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human TFR (Transferrin Receptor) Sandwich ELISA Kit Ready-To-Use (STJE0018881)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.58ng/mL
Detection Limit:	1.56-100ng/mL
Short Description:	This TFR Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	TFRC
Gene ID:	7037
Uniprot ID:	TFR1_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation. Stearoylation does not affect iron uptake. N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR). Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.
Function	Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2. (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
Protein Name	Transferrin Receptor Protein 1 Tr Tfr Tfr1 Trfr T9 P90 Cd Antigen Cd71 Cleaved Into - Transferrin Receptor Protein 1 - Serum Form Stfr
Database Links	Reactome: R-HSA-432722 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-8980692 Reactome: R-HSA-9013026 Reactome: R-HSA-9013106 Reactome: R-HSA-9013148 Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013406 Reactome: R-HSA-9013407 Reactome: R-HSA-9013408 Reactome: R-HSA-9013409 Reactome: R-HSA-9013423 Reactome: R-HSA-917977 Reactome: R-HSA-9696270 Reactome: R-HSA-9696273
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein Melanosome Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv Transferrin Receptor Protein 1 Serum Form: Secreted
Alternative ELISA Names	Transferrin Receptor Protein 1 ELISA kit Tr ELISA kit Tfr ELISA kit Tfr1 ELISA kit Trfr ELISA kit T9 ELISA kit P90 ELISA kit Cd Antigen Cd71 Cleaved Into - Transferrin Receptor Protein 1 - Serum Form ELISA kit Stfr ELISA kit TFRC ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human TFR (Transferrin Receptor) Sandwich ELISA Kit Ready-To-Use (STJE0018881)