Anti-Cleaved-F10-I235 antibody (216-265 aa) (STJ90082) STJ90082 上海玉博生物科技有限公司

Anti-Cleaved-F10-I235 antibody (216-265 aa) (STJ90082)

简单介绍

Anti-Cleaved-F10-I235 antibody (216-265 aa) (STJ90082)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cleaved-Coagulation factor X-I235 (216-265 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 ELISA 1:20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	F10
Gene ID:	2159
Uniprot ID:	FA10_HUMAN
Immunogen Region:	216-265 aa
Specificity:	Cleaved-Factor Xa activated HC (I235) Polyclonal Antibody detects endogenous levels of fragment of activated Factor Xa activated HC protein resulting from cleavage adjacent to I235.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human FA10 at the amino acid range 216-265

Post Translational Modifications	The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. Proteolytically cleaved and activated by cathepsin CTSG. The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway). The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Function	Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Protein Name	Coagulation Factor X Stuart Factor Stuart-Prower Factor Cleaved Into - Factor X Light Chain - Factor X Heavy Chain - Activated Factor Xa Heavy Chain
Database Links	Reactome: R-HSA-140834 Reactome: R-HSA-140837 Reactome: R-HSA-140875 Reactome: R-HSA-159740 Reactome: R-HSA-159763 Reactome: R-HSA-159782 Reactome: R-HSA-9672383 Reactome: R-HSA-9672396 Reactome: R-HSA-9673202
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Coagulation Factor X antibody Anti-Stuart Factor antibody Anti-Stuart-Prower Factor Cleaved Into - Factor X Light Chain - Factor X Heavy Chain - Activated Factor Xa Heavy Chain antibody Anti-F10 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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