Anti-Cleaved-F11-Glu19, Heavy Chain antibody (18-19) (STJA0005837) STJA0005837 上海玉博生物科技有限公司

Anti-Cleaved-F11-Glu19, Heavy Chain antibody (18-19) (STJA0005837)

简单介绍

Anti-Cleaved-F11-Glu19, Heavy Chain antibody (18-19) (STJA0005837)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cleaved-Coagulation factor XI-Glu19, Heavy Chain (18-19) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:1000-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	F11
Gene ID:	2160
Uniprot ID:	FA11_HUMAN
Immunogen Region:	18-19
Specificity:	This antibody detects endogenous levels of Human, Mouse FA11 (heavy chain, Cleaved-Glu19, protein was cleaved amino acid sequence between 18-19 )
Immunogen:	Synthesized peptide derived from human FA11 (heavy chain, Cleaved-Glu19)

Tissue Specificity	Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
Post Translational Modifications	N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite. Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
Function	Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Protein Name	Coagulation Factor Xi Fxi Plasma Thromboplastin Antecedent Pta Cleaved Into - Coagulation Factor Xia Heavy Chain - Coagulation Factor Xia Light Chain
Database Links	Reactome: R-HSA-140837 Reactome: R-HSA-9673221
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Coagulation Factor Xi antibody Anti-Fxi antibody Anti-Plasma Thromboplastin Antecedent antibody Anti-Pta Cleaved Into - Coagulation Factor Xia Heavy Chain - Coagulation Factor Xia Light Chain antibody Anti-F11 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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