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Human TICAM1 (Toll Like Receptor Adaptor Molecule 1) Sandwich ELISA Kit (STJE0012571)
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Human TICAM1 (Toll Like Receptor Adaptor Molecule 1) Sandwich ELISA Kit (STJE0012571)
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Human TICAM1 (Toll Like Receptor Adaptor Molecule 1) Sandwich ELISA Kit (STJE0012571)
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产品名称:
Human TICAM1 (Toll Like Receptor Adaptor Molecule 1) Sandwich ELISA Kit (STJE0012571)
产品型号:
STJE0012571
产品展商:
ST john's laboratory
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简单介绍
Human TICAM1 (Toll Like Receptor Adaptor Molecule 1) Sandwich ELISA Kit (STJE0012571)
产品描述
Applications:
ELISA
Reactivity:
Human
Note:
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:
0.124ng/mL
Detection Limit:
0.312-20ng/mL
Short Description:
This TICAM1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction:
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:
4.5 hrs
Gene Symbol:
TICAM1
Gene ID:
148022
Uniprot ID:
TCAM1_HUMAN
Sample Type:
tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Ubiquitously expressed but with higher levels in liver.
Post Translational Modifications
Phosphorylated by TBK1. Following activation, phosphorylated by TBK1 at Ser-210 in the pLxIS motif. The phosphorylated pLxIS motif constitutes an IRF3-binding motif, leading to recruitment of the transcription factor IRF3 to induce type-I interferons and other cytokines. Polyubiquitinated at Lys-229 by TRIM38 with 'Lys-48'-linked chains, leading to proteasomal degradation. Polyubiquitinated with 'Lys-6'- and 'Lys-33'-linked chains in a TRIM8-dependent manner.ubiquitination disrupts the interaction with TBK1 and subsequent interferon production. (Microbial infection) Cleaved and degraded by hepatitis A virus (HAV) protein 3CD allowing the virus to disrupt host TLR3 signaling. (Microbial infection) Cleaved by CVB3 protease 3C allowing the virus to disrupt host TLR3 signaling. (Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to disrupt host TLR3 signaling. (Microbial infection) Cleaved by protease 3C of human enterovirus D68 (EV68) allowing the virus to disrupt host TLR3 signaling. (Microbial infection) Cleaved by HCV protease NS3/4A, thereby disrupting TLR3 signaling and preventing the establishment of an antiviral state.
Function
Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.
Protein Name
Tir Domain-Containing Adapter Molecule 1
Ticam-1
Proline-Rich - Vinculin And Tir Domain-Containing Protein B
Putative Nf-Kappa-B-Activating Protein 502h
Toll-Interleukin-1 Receptor Domain-Containing Adapter Protein Inducing Interferon Beta
Myd88-3
Tir Domain-Containing Adapter Protein Inducing Ifn-Beta
Database Links
Reactome: R-HSA-140534
Reactome: R-HSA-166166
Reactome: R-HSA-168164
Reactome: R-HSA-168927
Reactome: R-HSA-1810476
Reactome: R-HSA-2562578
Reactome: R-HSA-5602566
Reactome: R-HSA-5602571
Reactome: R-HSA-9013957
Reactome: R-HSA-9013973
Reactome: R-HSA-9014325
Reactome: R-HSA-936964
Reactome: R-HSA-937041
Reactome: R-HSA-937072
Reactome: R-HSA-975163
Cellular Localisation
Cytoplasmic Vesicle
Autophagosome
Cytoplasm
Cytosol
Mitochondrion
Colocalizes With Ubqln1 In The Autophagosome
Colocalizes In The Cytosol With Ddx1
Ddx21 And Dhx36
Colocalizes In The Mitochondria With Ddx1 And Poly(I:c) Rna Ligand
The Multi-Helicase-Ticam1 Complex May Translocate To The Mitochondria Upon Poly(I:c) Rna Ligand Stimulation
Alternative ELISA Names
Tir Domain-Containing Adapter Molecule 1 ELISA kit
Ticam-1 ELISA kit
Proline-Rich - Vinculin And Tir Domain-Containing Protein B ELISA kit
Putative Nf-Kappa-B-Activating Protein 502h ELISA kit
Toll-Interleukin-1 Receptor Domain-Containing Adapter Protein Inducing Interferon Beta ELISA kit
Myd88-3 ELISA kit
Tir Domain-Containing Adapter Protein Inducing Ifn-Beta ELISA kit
TICAM1 ELISA kit
PRVTIRB ELISA kit
TRIF ELISA kit
output
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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