Human TICAM1 (Toll Like Receptor Adaptor Molecule 1) Sandwich ELISA Kit Ready-To-Use (STJE0018959) STJE0018959 上海玉博生物科技有限公司

Human TICAM1 (Toll Like Receptor Adaptor Molecule 1) Sandwich ELISA Kit Ready-To-Use (STJE0018959)

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产品名称：Human TICAM1 (Toll Like Receptor Adaptor Molecule 1) Sandwich ELISA Kit Ready-To-Use (STJE0018959)
产品型号：STJE0018959
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human TICAM1 (Toll Like Receptor Adaptor Molecule 1) Sandwich ELISA Kit Ready-To-Use (STJE0018959)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.124ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This TICAM1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	TICAM1
Gene ID:	148022
Uniprot ID:	TCAM1_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Ubiquitously expressed but with higher levels in liver.
Post Translational Modifications	Phosphorylated by TBK1. Following activation, phosphorylated by TBK1 at Ser-210 in the pLxIS motif. The phosphorylated pLxIS motif constitutes an IRF3-binding motif, leading to recruitment of the transcription factor IRF3 to induce type-I interferons and other cytokines. Polyubiquitinated at Lys-229 by TRIM38 with 'Lys-48'-linked chains, leading to proteasomal degradation. Polyubiquitinated with 'Lys-6'- and 'Lys-33'-linked chains in a TRIM8-dependent manner.ubiquitination disrupts the interaction with TBK1 and subsequent interferon production. (Microbial infection) Cleaved and degraded by hepatitis A virus (HAV) protein 3CD allowing the virus to disrupt host TLR3 signaling. (Microbial infection) Cleaved by CVB3 protease 3C allowing the virus to disrupt host TLR3 signaling. (Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to disrupt host TLR3 signaling. (Microbial infection) Cleaved by protease 3C of human enterovirus D68 (EV68) allowing the virus to disrupt host TLR3 signaling. (Microbial infection) Cleaved by HCV protease NS3/4A, thereby disrupting TLR3 signaling and preventing the establishment of an antiviral state.
Function	Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.
Protein Name	Tir Domain-Containing Adapter Molecule 1 Ticam-1 Proline-Rich - Vinculin And Tir Domain-Containing Protein B Putative Nf-Kappa-B-Activating Protein 502h Toll-Interleukin-1 Receptor Domain-Containing Adapter Protein Inducing Interferon Beta Myd88-3 Tir Domain-Containing Adapter Protein Inducing Ifn-Beta
Database Links	Reactome: R-HSA-140534 Reactome: R-HSA-166166 Reactome: R-HSA-168164 Reactome: R-HSA-168927 Reactome: R-HSA-1810476 Reactome: R-HSA-2562578 Reactome: R-HSA-5602566 Reactome: R-HSA-5602571 Reactome: R-HSA-9013957 Reactome: R-HSA-9013973 Reactome: R-HSA-9014325 Reactome: R-HSA-936964 Reactome: R-HSA-937041 Reactome: R-HSA-937072 Reactome: R-HSA-975163
Cellular Localisation	Cytoplasmic Vesicle Autophagosome Cytoplasm Cytosol Mitochondrion Colocalizes With Ubqln1 In The Autophagosome Colocalizes In The Cytosol With Ddx1 Ddx21 And Dhx36 Colocalizes In The Mitochondria With Ddx1 And Poly(I:c) Rna Ligand The Multi-Helicase-Ticam1 Complex May Translocate To The Mitochondria Upon Poly(I:c) Rna Ligand Stimulation
Alternative ELISA Names	Tir Domain-Containing Adapter Molecule 1 ELISA kit Ticam-1 ELISA kit Proline-Rich - Vinculin And Tir Domain-Containing Protein B ELISA kit Putative Nf-Kappa-B-Activating Protein 502h ELISA kit Toll-Interleukin-1 Receptor Domain-Containing Adapter Protein Inducing Interferon Beta ELISA kit Myd88-3 ELISA kit Tir Domain-Containing Adapter Protein Inducing Ifn-Beta ELISA kit TICAM1 ELISA kit PRVTIRB ELISA kit TRIF ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human TICAM1 (Toll Like Receptor Adaptor Molecule 1) Sandwich ELISA Kit Ready-To-Use (STJE0018959)