您好,欢迎来到仪表展览网!
请登录
免费注册
分享
微信
新浪微博
人人网
QQ空间
开心网
豆瓣
会员服务
进取版
标准版
尊贵版
|
设为首页
|
收藏
|
导航
|
帮助
|
移动端
|
官方微信扫一扫
微信扫一扫
收获行业前沿信息
产品
资讯
请输入产品名称
噪声分析仪
纺织检测仪器
Toc分析仪
PT-303红外测温仪
转矩测试仪
继电保护试验仪
定氮仪
首页
产品
专题
品牌
资料
展会
成功案例
网上展会
词多 效果好 就选易搜宝!
上海玉博生物科技有限公司
新增产品
|
公司简介
注册时间:
2014-10-23
联系人:
电话:
Email:
首页
公司简介
产品目录
公司新闻
技术文章
资料下载
成功案例
人才招聘
荣誉证书
联系我们
产品目录
A类
absolute antibody
a
a & g pharmaceuticals官网
a.g scientific
Aalto
Aalto Scientific
aaltobioreagents
aaltoscientific
aat
aat bioquest
B类
Bacharach Inc
Bachem
backman coulter
badrilla
Bangs
bangs laboratories
bangslab
bangslabs
Barnant Company
Barnstead International
C类
CASMASCI
C
Cadence Science
caisson labs
Calbiochem
CalBioreagents
calbiotech
California Bioscience
california bioscience2
california peptide research
D类
Dade-Behring
daiichi fine chemical
Dako
Davis Instruments
DB Biotech
dbbiotech
DBS
DCS
De Novo Software
deciphergen
E类
EpiCypher
eagle
Eagle BioSciences
Eagle Manufacturing
Eagle Manufacturing Company
Eagle Manufacturing Company/Eagle Mfg. Company
Eagle Thermoplastics Inc.
EarthOx
eastcoast
Eastwood Manufacturing Co.
F类
FabGennix
Falcon Safety
Falcon Safety Products Inc.
Fawcett Company Inc.
FD NEURO TECHNOLOGIES
FD NeuroTechnologies
fd neurotechnologies2
FDNeuroo
fdneurotech
fdneurotech/fd neurotechnologies/FD NEURO TECHNOLOGIES
G类
G C Fuller
GALAB technologies
gallusimmunotech
Gast Manufacturing, Inc.
Gawet Marble
GBD
gbi
gbi-inc
gbiosciences
GBP
H类
Haematologic Technologies
Haematologic Technologies Inc
hamilton
Hampton
Handyem
HANNA
hawksley
HBM
HBT
Hellma
I类
Isosep
IBA
IBA-go
ibexpharma
Ibidi
IBL
IBL-America
ibtsystems
ICLLab
Icosagen
J类
Jackson
Jackson ImmunoResearch
JCRB
jena bioscience
jenabioscience
JPC
JRS Medical
K类
Kalen Biomedical
Kamiya
kapabiosystems
katchem
katena
kentscientific
kerafast
KERRY
Kingfisher Biotech
Kollodis BioSciences
L类
Labfrontier
Labnet
labscientific
Labvision
Lancaster
larodan
LaysanBio
LC Laboratories
lclabs
LDN
M类
moradec
molzym
magsphere
Mabtech
Macherey-Nagel
macrocyclics
Macs Miltenyi
Magen
MagnaMedics
maravai lifesciences
N类
nanocomposix
Nexcelom Bioscience
nabertherm
Nalgene
Nano
NanoBac
NanoLight Technologies
nanoprobes
nanoscience
NANOSOFT POLYMERS
O类
Ocean NanoTech
OEM Concept
OET
ohaus
ohio valley specialty
oligoengine
Omega试剂盒
omicron Biochemicals
omicronbio
Omni International
P类
panagene
Polymer source
phosphorex
Pall
PANATecs
Panomics
panpath
Parafilm
PBL InterferonSource
Pel-Freez
Q类
QAbio
QBG
QED bioscience
QEDbioscience
Qiagen
Quansys Biosciences
Quanta Biosciences
quantabiodesign
quickzyme
Quidel
R类
rossix
R&D
Rainin
RayBiotech
RB
RBC bioscience
R-biopharm
RECI
Relia Tech
RELIATech
S类
Spirochrome
S&S
SABiosciences
salimetrics
Sanquin
Santa Cruz
sanyo
Sartorius
SBA
SBI
T类
terrace biotech
taiclone
Takara
TaqMan
targetingsystems
TCI
Techne
Technoclone
Tecrea
Ted Pella
U类
UBPBIO
U-Cytech
UmanDiagnostics
UnionBiometrica
unitedchem
Upstate
Us biological
Usb
usbio
Usbiological
V类
valasciences
Valley Biomedical
Varian
Vector
Vector Laboratories
Vectorlabs
verichem
veridex
viagenbiotech
ViennaLab
W类
Wako
warner
waters
werner bioAgents
whatman
WHO
Wieslab
worthington
wpiinc
WSU Monoclonal Antibody Center
X类
Xcessbio
X-Rite
Y类
Yakult
yesbiotech
YSL
Z类
zedira
ZENOAQ
ZeptoMetrix
zyagen
zyagen Laboratories
Zymed
Zymo Research
zytovision
5 prime
3-M Company
3hbiomedical
3h biomedical
3dhistech
3D Matrix
3D Biomatrix
胎牛血清
85ml离心管
密理博
5prime
4adi
4rtilab
实验仪器
实验试剂
细胞分离液
培养基
转染试剂
外泌体提取试剂盒
硫酸钠葡聚糖
胶原酶
实验耗材
封板膜
细胞计数板
测试
当前位置:
首页
>>>
产品目录
>>>
S类
>>> 
ST john's laboratory
仪表展览网
>>>
展馆展区
>>>
Human Tie2 (TEK Tyrosine Kinase, Endothelial) Sandwich ELISA Kit (STJE0007243)
>
Human Tie2 (TEK Tyrosine Kinase, Endothelial) Sandwich ELISA Kit (STJE0007243)
产品资料
Human Tie2 (TEK Tyrosine Kinase, Endothelial) Sandwich ELISA Kit (STJE0007243)
如果您对该产品感兴趣的话,可以
产品名称:
Human Tie2 (TEK Tyrosine Kinase, Endothelial) Sandwich ELISA Kit (STJE0007243)
产品型号:
STJE0007243
产品展商:
ST john's laboratory
产品文档:
无相关文档
简单介绍
Human Tie2 (TEK Tyrosine Kinase, Endothelial) Sandwich ELISA Kit (STJE0007243)
产品描述
Applications:
ELISA
Reactivity:
Human
Note:
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:
0.52ng/mL
Detection Limit:
1.56-100ng/mL
Short Description:
This Tie2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction:
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:
4.5 hrs
Gene Symbol:
TEK
Gene ID:
7010
Uniprot ID:
TIE2_HUMAN
Sample Type:
serum, plasma, tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Detected in umbilical vein endothelial cells. Proteolytic processing gives rise to a soluble extracellular domain that is detected in blood plasma (at protein level). Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.
Post Translational Modifications
Proteolytic processing leads to the shedding of the extracellular domain (soluble TIE-2 alias sTIE-2). Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Autophosphorylation occurs in a sequential manner, where Tyr-992 in the kinase activation loop is phosphorylated first, followed by autophosphorylation at Tyr-1108 and at additional tyrosine residues. ANGPT1-induced phosphorylation is impaired during hypoxia, due to increased expression of ANGPT2. Phosphorylation is important for interaction with GRB14, PIK3R1 and PTPN11. Phosphorylation at Tyr-1102 is important for interaction with SHC1, GRB2 and GRB7. Phosphorylation at Tyr-1108 is important for interaction with DOK2 and for coupling to downstream signal transduction pathways in endothelial cells. Dephosphorylated by PTPRB. Ubiquitinated. The phosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
Function
Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of pro-inflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1.SHC1 and TIE1.
Protein Name
Angiopoietin-1 Receptor
Endothelial Tyrosine Kinase
Tunica Interna Endothelial Cell Kinase
Tyrosine Kinase With Ig And Egf Homology Domains-2
Tyrosine-Protein Kinase Receptor Tek
Tyrosine-Protein Kinase Receptor Tie-2
Htie2
P140 Tek
Cd Antigen Cd202b
Database Links
Reactome: R-HSA-210993
Reactome: R-HSA-5673001
Cellular Localisation
Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Focal Adhesion
Cytoplasm
Cytoskeleton
Secreted
Recruited To Cell-Cell Contacts In Quiescent Endothelial Cells
Colocalizes With The Actin Cytoskeleton And At Actin Stress Fibers During Cell Spreading
Recruited To The Lower Surface Of Migrating Cells
Especially The Rear End Of The Cell
Proteolytic Processing Gives Rise To A Soluble Extracellular Domain That Is Secreted
Alternative ELISA Names
Angiopoietin-1 Receptor ELISA kit
Endothelial Tyrosine Kinase ELISA kit
Tunica Interna Endothelial Cell Kinase ELISA kit
Tyrosine Kinase With Ig And Egf Homology Domains-2 ELISA kit
Tyrosine-Protein Kinase Receptor Tek ELISA kit
Tyrosine-Protein Kinase Receptor Tie-2 ELISA kit
Htie2 ELISA kit
P140 Tek ELISA kit
Cd Antigen Cd202b ELISA kit
TEK ELISA kit
TIE2 ELISA kit
VMCM ELISA kit
VMCM1 ELISA kit
output
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
产品留言
标题
联系人
联系电话
内容
验证码
点击换一张
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!
温馨提示:为规避购买风险,建议您在购买前务必确认供应商资质与产品质量。
免责申明:以上内容为注册会员自行发布,若信息的真实性、合法性存在争议,平台将会监督协助处理,
欢迎举报
产品留言
标题
内容
联系人
联系电话
电子邮件
公司名称
联系地址
验证码
点击换一张
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!
相关产品
Anti-Pan myristoylation antibody STJ98665
ST john's laboratory中国代理商2020
Anti-14-3-3 beta/Theta antibody (1-100) [S1MR] (STJ11103651) STJ11103651
Anti-14-3-3 Beta/Zeta antibody (151-200 aa) (STJ91368) STJ91368
Anti-14-3-3 sigma/Stratifin antibody (Internal) (STJ70838) STJ70838-100
Anti-14-3-3 sigma/Stratifin, Biotinylated antibody (Internal) {Biotin} (STJ73293) STJ73293-100
Anti-14-3-3 tau/YWHAQ antibody (Internal) (STJ71355) STJ71355-100
Anti-2 NA-O-methyl-2mA antibody (STJ11100889) STJ11100889
Anti-2 NA-O-methylcytidine/Cm antibody (STJ11103959) STJ11103959
Anti-2 NA-O-methylcytidine/Cm antibody [S4061RM] (STJ11104061) STJ11104061
Anti-2019-covid N protein antibody (STJA0010175) STJA0010175
Anti-2019-covid N protein antibody (STJA0010176) STJA0010176
Anti-2019-nCoV antibody [S0MR] (STJ11101210) STJ11101210
Anti-2019-nCoV antibody [S1MR] (STJ11101211) STJ11101211
Anti-25-OH-VD antibody [S5669RM] (STJ11105669) STJ11105669
若网站内容侵犯到您的权益,请通过网站上的联系方式及时联系我们修改或删除
沪公网安备 31011002002624号