Human TLR1 (Toll Like Receptor 1) Sandwich ELISA Kit (STJE0012626) STJE0012626 上海玉博生物科技有限公司

Human TLR1 (Toll Like Receptor 1) Sandwich ELISA Kit (STJE0012626)

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产品名称：Human TLR1 (Toll Like Receptor 1) Sandwich ELISA Kit (STJE0012626)
产品型号：STJE0012626
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human TLR1 (Toll Like Receptor 1) Sandwich ELISA Kit (STJE0012626)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.072ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This TLR1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	TLR1
Gene ID:	7096
Uniprot ID:	TLR1_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.
Post Translational Modifications
Function	Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Protein Name	Toll-Like Receptor 1 Toll/Interleukin-1 Receptor-Like Protein Til Cd Antigen Cd281
Database Links	Reactome: R-HSA-1236974 Reactome: R-HSA-1461957 Reactome: R-HSA-166058 Reactome: R-HSA-168179 Reactome: R-HSA-5602498 Reactome: R-HSA-5603041 Reactome: R-HSA-5686938 Reactome: R-HSA-9705671
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Cytoplasmic Vesicle Phagosome Membrane Membrane Raft Golgi Apparatus Does Not Reside In Lipid Rafts Before Stimulation But Accumulates Increasingly In The Raft Upon The Presence Of The Microbial Ligand In Response To Triacylated Lipoproteins Tlr2:Tlr1 Heterodimers Are Recruited In Lipid Rafts This Recruitment Determine The Intracellular Targeting To The Golgi Apparatus
Alternative ELISA Names	Toll-Like Receptor 1 ELISA kit Toll/Interleukin-1 Receptor-Like Protein ELISA kit Til ELISA kit Cd Antigen Cd281 ELISA kit TLR1 ELISA kit KIAA0012 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human TLR1 (Toll Like Receptor 1) Sandwich ELISA Kit (STJE0012626)