Anti-Cleaved-IL18-Tyr37 antibody [S5289RM] (STJ11105289) STJ11105289 上海玉博生物科技有限公司

Anti-Cleaved-IL18-Tyr37 antibody [S5289RM] (STJ11105289)

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产品名称：Anti-Cleaved-IL18-Tyr37 antibody [S5289RM] (STJ11105289)
产品型号：STJ11105289
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Cleaved-IL18-Tyr37 antibody [S5289RM] (STJ11105289)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-Cleaved-Interleukin-18-Tyr37 is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	S5289RM
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	IL18
Gene ID:	3606
Uniprot ID:	IL18_HUMAN
Immunogen:	A synthetic peptide corresponding to residues surrounding Tyr37 of human IL18 (NP_001553.1).

Post Translational Modifications	The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.
Function	Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
Protein Name	Interleukin-18 Il-18 Iboctadekin Interferon Gamma-Inducing Factor Ifn-Gamma-Inducing Factor Interleukin-1 Gamma Il-1 Gamma
Database Links	Reactome: R-HSA-448706 Reactome: R-HSA-5620971 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-9012546 Q14116-2 Reactome: R-HSA-9660826
Cellular Localisation	Cytoplasm Secreted The Precursor Is Cytosolic In Response To Inflammasome-Activating Signals Cleaved And Secreted Mature Form Is Secreted And Released In The Extracellular Milieu By Passing Through The Gasdermin-D (Gsdmd) Pore In Contrast The Precursor Form Is Not Released Due To The Presence Of An Acidic Region That Is Proteolytically Removed By Casp1 During Maturation The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
Alternative Antibody Names	Anti-Interleukin-18 antibody Anti-Il-18 antibody Anti-Iboctadekin antibody Anti-Interferon Gamma-Inducing Factor antibody Anti-Ifn-Gamma-Inducing Factor antibody Anti-Interleukin-1 Gamma antibody Anti-Il-1 Gamma antibody Anti-IL18 antibody Anti-IGIF antibody Anti-IL1F4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Cleaved-IL18-Tyr37 antibody [S5289RM] (STJ11105289)