Anti-Cleaved-ITGA8-Arg906, Heavy Chain antibody (906-907) (STJA0005874) STJA0005874 上海玉博生物科技有限公司

Anti-Cleaved-ITGA8-Arg906, Heavy Chain antibody (906-907) (STJA0005874)

简单介绍

Anti-Cleaved-ITGA8-Arg906, Heavy Chain antibody (906-907) (STJA0005874)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cleaved-Integrin alpha-8-Arg906, Heavy Chain (906-907) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 IHC-p 1:50-300
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ITGA8
Gene ID:	8516
Uniprot ID:	ITA8_HUMAN
Immunogen Region:	906-907
Specificity:	This antibody detects endogenous levels of Human, Mouse, Rat ITGA8 (heavy chain, Cleaved-Arg906, protein was cleaved amino acid sequence between 906-907 )
Immunogen:	Synthesized peptide derived from human ITGA8 (heavy chain, Cleaved-Arg906)

Tissue Specificity	Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
Function	Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
Protein Name	Integrin Alpha-8 Cleaved Into - Integrin Alpha-8 Heavy Chain - Integrin Alpha-8 Light Chain
Database Links	Reactome: R-HSA-2129379 Reactome: R-HSA-216083 Reactome: R-HSA-2173789 Reactome: R-HSA-3000178
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein Cell Membrane
Alternative Antibody Names	Anti-Integrin Alpha-8 Cleaved Into - Integrin Alpha-8 Heavy Chain - Integrin Alpha-8 Light Chain antibody Anti-ITGA8 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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