Anti-Cleaved-MMP3-F100 antibody (81-130 aa) (STJ90065) STJ90065 上海玉博生物科技有限公司

Anti-Cleaved-MMP3-F100 antibody (81-130 aa) (STJ90065)

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产品名称：Anti-Cleaved-MMP3-F100 antibody (81-130 aa) (STJ90065)
产品型号：STJ90065
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Cleaved-MMP3-F100 antibody (81-130 aa) (STJ90065)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cleaved-Stromelysin-1-F100 (81-130 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 ELISA 1:20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	MMP3
Gene ID:	4314
Uniprot ID:	MMP3_HUMAN
Immunogen Region:	81-130 aa
Specificity:	Cleaved-MMP-3 (F100) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-3 protein resulting from cleavage adjacent to F100.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human MMP3 at the amino acid range 81-130

Function	Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V.collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Acts also intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage. In addition, plays a role in immune response and possesses antiviral activity against various viruses such as vesicular stomatitis virus, influenza A virus (H1N1) and human herpes virus 1. Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities.
Protein Name	Stromelysin-1 Sl-1 Matrix Metalloproteinase-3 Mmp-3 Transin-1
Database Links	Reactome: R-HSA-1442490 Reactome: R-HSA-1474228 Reactome: R-HSA-1592389 Reactome: R-HSA-2022090 Reactome: R-HSA-2179392 Reactome: R-HSA-6785807 Reactome: R-HSA-9009391
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix Nucleus Cytoplasm
Alternative Antibody Names	Anti-Stromelysin-1 antibody Anti-Sl-1 antibody Anti-Matrix Metalloproteinase-3 antibody Anti-Mmp-3 antibody Anti-Transin-1 antibody Anti-MMP3 antibody Anti-STMY1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Cleaved-MMP3-F100 antibody (81-130 aa) (STJ90065)