Human TLR5 (Toll Like Receptor 5) Sandwich ELISA Kit (STJE0012638) STJE0012638 上海玉博生物科技有限公司

Human TLR5 (Toll Like Receptor 5) Sandwich ELISA Kit (STJE0012638)

简单介绍

Human TLR5 (Toll Like Receptor 5) Sandwich ELISA Kit (STJE0012638)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.135ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This TLR5 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	TLR5
Gene ID:	7100
Uniprot ID:	TLR5_HUMAN
Sample Type:	tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Highly expressed on the basolateral surface of intestinal epithelia. Expressed also in other cells such as lung epithelial cells.
Post Translational Modifications	Phosphorylated at Ser-805 by PKD/PRKD1.phosphorylation induces the production of inflammatory cytokines. Phosphorylated at Tyr-798 upon flagellin binding.required for signaling.
Function	Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota. Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response. Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life.
Protein Name	Toll-Like Receptor 5 Toll/Interleukin-1 Receptor-Like Protein 3
Database Links	Reactome: R-HSA-168176 Reactome: R-HSA-5602680 Reactome: R-HSA-5603037 Reactome: R-HSA-975871
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative ELISA Names	Toll-Like Receptor 5 ELISA kit Toll/Interleukin-1 Receptor-Like Protein 3 ELISA kit TLR5 ELISA kit TIL3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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