Human TLR6 (Toll Like Receptor 6) Sandwich ELISA Kit Ready-To-Use (STJE0019027) STJE0019027 上海玉博生物科技有限公司

Human TLR6 (Toll Like Receptor 6) Sandwich ELISA Kit Ready-To-Use (STJE0019027)

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产品名称：Human TLR6 (Toll Like Receptor 6) Sandwich ELISA Kit Ready-To-Use (STJE0019027)
产品型号：STJE0019027
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human TLR6 (Toll Like Receptor 6) Sandwich ELISA Kit Ready-To-Use (STJE0019027)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.112ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This TLR6 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	TLR6
Gene ID:	10333
Uniprot ID:	TLR6_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.
Post Translational Modifications
Function	Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.
Protein Name	Toll-Like Receptor 6 Cd Antigen Cd286
Database Links	Reactome: R-HSA-1236974 Reactome: R-HSA-166058 Reactome: R-HSA-168188 Reactome: R-HSA-5602498 Reactome: R-HSA-5603041 Reactome: R-HSA-5686938
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Cytoplasmic Vesicle Phagosome Membrane Membrane Raft Golgi Apparatus Upon Complex Formation With Cd36 And Tlr4 Internalized Through Dynamin-Dependent Endocytosis Does Not Reside In Lipid Rafts Before Stimulation But Accumulates Increasingly In The Raft Upon The Presence Of The Microbial Ligand In Response To Diacylated Lipoproteins Tlr2:Tlr6 Heterodimers Are Recruited In Lipid Rafts This Recruitment Determine The Intracellular Targeting To The Golgi Apparatus
Alternative ELISA Names	Toll-Like Receptor 6 ELISA kit Cd Antigen Cd286 ELISA kit TLR6 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human TLR6 (Toll Like Receptor 6) Sandwich ELISA Kit Ready-To-Use (STJE0019027)