Human TLR8 (Toll Like Receptor 8) Sandwich ELISA Kit (STJE0012643) STJE0012643 上海玉博生物科技有限公司

Human TLR8 (Toll Like Receptor 8) Sandwich ELISA Kit (STJE0012643)

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产品名称：Human TLR8 (Toll Like Receptor 8) Sandwich ELISA Kit (STJE0012643)
产品型号：STJE0012643
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human TLR8 (Toll Like Receptor 8) Sandwich ELISA Kit (STJE0012643)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.108ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This TLR8 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	TLR8
Gene ID:	51311
Uniprot ID:	TLR8_HUMAN
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Expressed in myeloid dendritic cells, monocytes, and monocyte-derived dendritic cells.
Post Translational Modifications	Ubiquitinated by RNF216.leading to degradation by the proteasome. Proteolytic processing occurs in monocytes and monocyte-derived macrophages by both furin-like proprotein convertase and cathepsins. The cleavage is necessary for dimer formation and subsequent activation.
Function	Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively.
Protein Name	Toll-Like Receptor 8 Cd Antigen Cd288
Database Links	Reactome: R-HSA-1679131 Reactome: R-HSA-168181 Reactome: R-HSA-9705671
Cellular Localisation	Endosome Membrane Single-Pass Type I Membrane Protein Endosomal Localization Confers Distinctive Proteolytic Processing
Alternative ELISA Names	Toll-Like Receptor 8 ELISA kit Cd Antigen Cd288 ELISA kit TLR8 ELISA kit UNQ249 ELISA kit PRO286 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human TLR8 (Toll Like Receptor 8) Sandwich ELISA Kit (STJE0012643)