Human TMEM27 (Transmembrane Protein 27) Sandwich ELISA Kit (STJE0012651) STJE0012651 上海玉博生物科技有限公司

Human TMEM27 (Transmembrane Protein 27) Sandwich ELISA Kit (STJE0012651)

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产品名称：Human TMEM27 (Transmembrane Protein 27) Sandwich ELISA Kit (STJE0012651)
产品型号：STJE0012651
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human TMEM27 (Transmembrane Protein 27) Sandwich ELISA Kit (STJE0012651)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.057ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This TMEM27 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	CLTRN
Gene ID:	57393
Uniprot ID:	CLTRN_HUMAN
Sample Type:	tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Kidney.collecting ducts. Pancreas.beta cells of islets.
Post Translational Modifications	Glycosylated. Glycosylation is required for plasma membrane localization and for its cleavage by BACE2. Proteolytically processed in pancreatic beta cells by BACE2 leading to the generation and extracellular release of soluble CLTRN, and a corresponding cell-associated C-terminal fragment which is later cleaved by gamma-secretase. This shedding process inactivates CLTRN. Three cleavage sites have been identified for BACE2, two clustered sites after Phe-116 and Leu-118 and a more membrane proximal site at Phe-125.the preferred BACE2 cleavage site seems to be between Phe-125 and Leu-126, Phe-116 and Leu-118 act as alternative sites.
Function	Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication.
Protein Name	Collectrin Transmembrane Protein 27
Database Links	Reactome: R-HSA-264876
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Localizes To The Brush Border Membranes Of Cells In The Proximal Tubules Of Kidney Colocalizes With Slc6a19 In The Early Proximal S1 Tubule
Alternative ELISA Names	Collectrin ELISA kit Transmembrane Protein 27 ELISA kit CLTRN ELISA kit TMEM27 ELISA kit UNQ679 ELISA kit PRO1312 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human TMEM27 (Transmembrane Protein 27) Sandwich ELISA Kit (STJE0012651)