Human TMEM2L (Transmembrane Protein 2 Like Protein) Sandwich ELISA Kit Ready-To-Use (STJE0019042) STJE0019042 上海玉博生物科技有限公司

Human TMEM2L (Transmembrane Protein 2 Like Protein) Sandwich ELISA Kit Ready-To-Use (STJE0019042)

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产品名称：Human TMEM2L (Transmembrane Protein 2 Like Protein) Sandwich ELISA Kit Ready-To-Use (STJE0019042)
产品型号：STJE0019042
产品展商：ST john's laboratory
产品文档：无相关文档

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Human TMEM2L (Transmembrane Protein 2 Like Protein) Sandwich ELISA Kit Ready-To-Use (STJE0019042)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.052ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This TMEM2L Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	CEMIP
Gene ID:	57214
Uniprot ID:	CEMIP_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Expressed in dermal and in synovial fibroblasts. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in both ductal carcinoma and invasive breast cancer cells compared with benign epithelial cells (at protein level). Strongly expressed in brain, placenta, prostate, breast, lung and testis. Expressed in fibroblasts, epithelial cells and cancer cells. In ear, it is specifically expressed in inner ear. Expressed in cochlea and vestibule tissues. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in colon adenocarcinomas compared with normal colonic mucosas. Strongly expressed in breast cancer as compared to normal breast tissue.
Post Translational Modifications	N-glycosylated.glycosylation is not necessary for HA-binding.
Function	Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.
Protein Name	Cell Migration-Inducing And Hyaluronan-Binding Protein Hyaluronan Binding Protein Involved In Hyaluronan Depolymerization
Database Links	Reactome: R-HSA-2142850
Cellular Localisation	Nucleus Cytoplasm Endoplasmic Reticulum Cell Membrane Membrane Clathrin-Coated Pit Secreted Retained In The Endoplasmic Reticulum (Er) In A Hspa5/Bip-Dependent Manner Colocalized With Clathrin Heavy Chain/Cltc In Clathrin-Coated Vesicles Strongly Detected In The Cytoplasm Of Breast Carcinoma Cells Whereas Poorly Detected In Adjacent Normal Epithelial Cells Stromal Cells Or Benign Breast Tissues Localized In The Nucleus And Cytoplasm Of Colon Adenocarcinomas
Alternative ELISA Names	Cell Migration-Inducing And Hyaluronan-Binding Protein ELISA kit Hyaluronan Binding Protein Involved In Hyaluronan Depolymerization ELISA kit CEMIP ELISA kit HYBID ELISA kit KIAA1199 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human TMEM2L (Transmembrane Protein 2 Like Protein) Sandwich ELISA Kit Ready-To-Use (STJE0019042)