Human TNFaIP6 (Tumor Necrosis Factor Alpha Induced Protein 6) Sandwich ELISA Kit (STJE0012676) STJE0012676 上海玉博生物科技有限公司

Human TNFaIP6 (Tumor Necrosis Factor Alpha Induced Protein 6) Sandwich ELISA Kit (STJE0012676)

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产品名称：Human TNFaIP6 (Tumor Necrosis Factor Alpha Induced Protein 6) Sandwich ELISA Kit (STJE0012676)
产品型号：STJE0012676
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human TNFaIP6 (Tumor Necrosis Factor Alpha Induced Protein 6) Sandwich ELISA Kit (STJE0012676)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.056ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This TNFaIP6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	TNFAIP6
Gene ID:	7130
Uniprot ID:	TSG6_HUMAN
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Expressed in airway epithelium and submucosal gland (at protein level). Colocalizes with bikunin at the ciliary border. Present in bronchoalveolar lavage fluid (at protein level). Expressed in mesenchymal stem cells. Found in the synovial fluid of patients with rheumatoid arthritis.
Post Translational Modifications	N-glycosylated.
Function	Major regulator of extracellular matrix organization during tissue remodeling. Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves the ester bond between the C-terminus of the HC and GalNAc residue of the chondroitin sulfate chain in I-alpha-I complex followed by transesterification of the HC to hyaluronan. In the process, potentiates the antiprotease function of I-alpha-I complex through release of free bikunin. Acts as a catalyst in the formation of hyaluronan-HC oligomers and hyaluronan-rich matrix surrounding the cumulus cell-oocyte complex, a necessary step for oocyte fertilization. Assembles hyaluronan in pericellular matrices that serve as platforms for receptor clustering and signaling. Enables binding of hyaluronan deposited on the surface of macrophages to LYVE1 on lymphatic endothelium and facilitates macrophage extravasation. Alters hyaluronan binding to functionally latent CD44 on vascular endothelium, switching CD44 into an active state that supports leukocyte rolling. Modulates the interaction of chemokines with extracellular matrix components and proteoglycans on endothelial cell surface, likely preventing chemokine gradient formation. In a negative feedback mechanism, may limit excessive neutrophil recruitment at inflammatory sites by antagonizing the association of CXCL8 with glycosaminoglycans on vascular endothelium. Has a role in osteogenesis and bone remodeling. Inhibits BMP2-dependent differentiation of mesenchymal stem cell to osteoblasts. Protects against bone erosion during inflammation by inhibiting TNFSF11/RANKL-dependent osteoclast activation.
Protein Name	Tumor Necrosis Factor-Inducible Gene 6 Protein Hyaluronate-Binding Protein Tnf-Stimulated Gene 6 Protein Tsg-6 Tumor Necrosis Factor Alpha-Induced Protein 6 Tnf Alpha-Induced Protein 6
Database Links	Reactome: R-HSA-6798695
Cellular Localisation	Secreted
Alternative ELISA Names	Tumor Necrosis Factor-Inducible Gene 6 Protein ELISA kit Hyaluronate-Binding Protein ELISA kit Tnf-Stimulated Gene 6 Protein ELISA kit Tsg-6 ELISA kit Tumor Necrosis Factor Alpha-Induced Protein 6 ELISA kit Tnf Alpha-Induced Protein 6 ELISA kit TNFAIP6 ELISA kit TSG6 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human TNFaIP6 (Tumor Necrosis Factor Alpha Induced Protein 6) Sandwich ELISA Kit (STJE0012676)