Anti-Cleaved-NOTCH4-V1432 antibody (1401-1450 aa) (STJ90070) STJ90070 上海玉博生物科技有限公司

Anti-Cleaved-NOTCH4-V1432 antibody (1401-1450 aa) (STJ90070)

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产品名称：Anti-Cleaved-NOTCH4-V1432 antibody (1401-1450 aa) (STJ90070)
产品型号：STJ90070
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Cleaved-NOTCH4-V1432 antibody (1401-1450 aa) (STJ90070)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Mouse/Monkey
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Cleaved-Neurogenic locus notch homolog protein 4-V1432 (1401-1450 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 ELISA 1:5000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	NOTCH4
Gene ID:	4855
Uniprot ID:	NOTC4_HUMAN
Immunogen Region:	1401-1450 aa
Specificity:	Cleaved-Notch 4 (V1432) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 4 protein resulting from cleavage adjacent to V1432.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human NOTCH4 at the amino acid range 1401-1450

Post Translational Modifications	Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane. Phosphorylated.
Function	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.
Protein Name	Neurogenic Locus Notch Homolog Protein 4 Notch 4 Hnotch4 Cleaved Into - Notch 4 Extracellular Truncation - Notch 4 Intracellular Domain
Database Links	Reactome: R-HSA-1912399 Reactome: R-HSA-1912408 Reactome: R-HSA-1912420 Reactome: R-HSA-350054 Reactome: R-HSA-5083630 Reactome: R-HSA-9013695 Reactome: R-HSA-9013700 Reactome: R-HSA-9604323
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Notch 4 Intracellular Domain: Nucleus Following Proteolytical Processing Nicd Is Translocated To The Nucleus
Alternative Antibody Names	Anti-Neurogenic Locus Notch Homolog Protein 4 antibody Anti-Notch 4 antibody Anti-Hnotch4 Cleaved Into - Notch 4 Extracellular Truncation - Notch 4 Intracellular Domain antibody Anti-NOTCH4 antibody Anti-INT3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Cleaved-NOTCH4-V1432 antibody (1401-1450 aa) (STJ90070)