Anti-CLEC4A antibody (1-100) (STJ23167) STJ23167 上海玉博生物科技有限公司

Anti-CLEC4A antibody (1-100) (STJ23167)

如果您对该产品感兴趣的话，可以
产品名称：Anti-CLEC4A antibody (1-100) (STJ23167)
产品型号：STJ23167
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CLEC4A antibody (1-100) (STJ23167)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CLEC4A (1-100) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CLEC4A
Gene ID:	50856
Uniprot ID:	CLC4A_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLEC4A (Q9UMR7).
Immunogen Sequence:	MTSEITYAEVRFKNEFKSSG INTASSAASKERTAPHKSNT GFPKLLCASLLIFFLLLAIS FFIAFVIFFQKYSQLLEKKT TKELVHTTLECVKKNMPVEE

Tissue Specificity	Expressed preferentially in hematopoietic tissues. Expressed in all circulating Ag-presenting cells such as dendritic cells, myeloid cells, monocytes, macrophages, B-cells and epidermal Langerhans cells (at protein level). Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus.
Function	C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. (Microbial infection) Involved in the interaction between HIV-1 virus and dendritic cells. Enhances HIV-1 binding/entry and virus infection. Requires ITIM motif-associated signal transduction pathway involving phosphatases PTPN6 and PTPN11, SYK, Src kinases and MAP kinases.
Protein Name	C-Type Lectin Domain Family 4 Member A C-Type Lectin Ddb27 C-Type Lectin Superfamily Member 6 Dendritic Cell Immunoreceptor Lectin-Like Immunoreceptor Cd Antigen Cd367
Database Links	Reactome: R-HSA-5621480
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein Extracellular Side
Alternative Antibody Names	Anti-C-Type Lectin Domain Family 4 Member A antibody Anti-C-Type Lectin Ddb27 antibody Anti-C-Type Lectin Superfamily Member 6 antibody Anti-Dendritic Cell Immunoreceptor antibody Anti-Lectin-Like Immunoreceptor antibody Anti-Cd Antigen Cd367 antibody Anti-CLEC4A antibody Anti-CLECSF6 antibody Anti-DCIR antibody Anti-LLIR antibody Anti-HDCGC13P antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Anti-CLEC4A antibody (1-100) (STJ23167)