Anti-CLEC4E antibody (46-96 aa) (STJ194562) STJ194562 上海玉博生物科技有限公司

Anti-CLEC4E antibody (46-96 aa) (STJ194562)

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产品名称：Anti-CLEC4E antibody (46-96 aa) (STJ194562)
产品型号：STJ194562
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CLEC4E antibody (46-96 aa) (STJ194562)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-C-type lectin domain family 4 member E (46-96 aa) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CLEC4E
Gene ID:	26253
Uniprot ID:	CLC4E_HUMAN
Immunogen Region:	46-96 aa
Specificity:	This antibody detects endogenous levels of CLC4E at Human/Mouse/Rat
Immunogen:	Synthesized peptide derived from the human CLC4E at the amino acid range 46-96

Function	Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions. Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation. Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue.
Protein Name	C-Type Lectin Domain Family 4 Member E C-Type Lectin Superfamily Member 9 Macrophage-Inducible C-Type Lectin Mincle
Database Links	Reactome: R-HSA-5621480
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein Cell Projection Phagocytic Cup
Alternative Antibody Names	Anti-C-Type Lectin Domain Family 4 Member E antibody Anti-C-Type Lectin Superfamily Member 9 antibody Anti-Macrophage-Inducible C-Type Lectin antibody Anti-Mincle antibody Anti-CLEC4E antibody Anti-CLECSF9 antibody Anti-MINCLE antibody Anti-UNQ218 antibody Anti-PRO244 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CLEC4E antibody (46-96 aa) (STJ194562)