Human TNPO1 (Transportin-1) CLIA Kit (STJC0000955) STJC0000955 上海玉博生物科技有限公司

Human TNPO1 (Transportin-1) CLIA Kit (STJC0000955)

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产品名称：Human TNPO1 (Transportin-1) CLIA Kit (STJC0000955)
产品型号：STJC0000955
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human TNPO1 (Transportin-1) CLIA Kit (STJC0000955)

产品描述

Applications:	CLIA
Reactivity:	Human
Note:	FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Sensitivity:	0.38ng/mL
Detection Limit:	0.63~40ng/mL
Short Description:	This human TNPO1 kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.

Storage Instruction:	If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual.
Assay Time:	3.5h
Detection:	Chemiluminescence

Gene Symbol:	TNPO1
Gene ID:	3842
Uniprot ID:	TNPO1_HUMAN
Specificity:	This kit recognizes Human TNPO1 in samples. No significant cross-reactivity or interference between Human TNPO1 and analogues was observed.
Sample Type:	Serum, plasma and other biological fluids

Function	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates nuclear import of SRP19. Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner. (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
Protein Name	Transportin-1 Importin Beta-2 Karyopherin Beta-2 M9 Region Interaction Protein Mip
Database Links	Reactome: R-HSA-450513 Reactome: R-HSA-5620924 Reactome: R-HSA-9615933
Cellular Localisation	Cytoplasm Nucleus
Alternative CLIA Names	Transportin-1 CLIA kit Importin Beta-2 CLIA kit Karyopherin Beta-2 CLIA kit M9 Region Interaction Protein CLIA kit Mip CLIA kit TNPO1 CLIA kit KPNB2 CLIA kit MIP1 CLIA kit TRN CLIA kit
Specificity	This kit recognizes Human TNPO1 in samples. No significant cross-reactivity or interference between Human TNPO1 and analogues was observed.
Reproducibility	Both intra-CV and inter-CV are

Information sourced from Uniprot.org

Item Specifications Storage

Micro CLIA Plate (Dismountable)	96T: 8 wells ×12 strips strips	-20℃, 6 months
Reference Standard	96T: 2 vials 48T: 1 vial	-20℃, 6 months
Concentrated Biotinylated Detection Ab (100×)	96T: 1 vial, 120 μL 60 μL	-20℃, 6 months
Concentrated HRP Conjugate (100×)	96T: 1 vial, 120 μL 60 μL	-20℃ (Protect from light), 6 months
Reference Standard & Sample Diluent	1 vial, 20 mL	2-8°C, 6 months
Biotinylated Detection Ab Diluent	1 vial, 14 mL	2-8°C, 6 months
HRP Conjugate Diluent	1 vial, 14 mL	2-8°C, 6 months
Concentrated Wash Buffer (25×)	1 vial, 30 mL	2-8°C, 6 months
Substrate Reagent A	1 vial, 5 mL	2-8℃ (Protect from light)
Substrate Reagent B	1 vial, 5 mL	2-8℃ (Protect from light)
Plate Sealer	5 pieces
Manual	1 copy
Certificate of Analysis	1 copy

Sample Type Range (%) Average Recovery (%)

Serum(n=8)	93-109	99
EDTA plasma(n=8)	88-104	95
Cell culture media(n=8)	94-109	100

Intra-assay Precision Intra-assay Precision Intra-assay Precision Inter-assay Precision Inter-assay Precision Inter-assay Precision

Sample	1.00	2.00	3.00	1.00	2.00	3.00
n	20.00	20.00	20.00	20.00	20.00	20.00
Mean (ng/mL)	1.85	4.80	19.99	1.91	4.47	20.37
Standard deviation	0.18	0.53	1.58	0.23	0.47	1.30
CV (%)	9.73	11.04	7.90	12.04	10.51	6.38

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human TNPO1 (Transportin-1) CLIA Kit (STJC0000955)