Human TNS3 (Tensin 3) Sandwich ELISA Kit Ready-To-Use (STJE0019117) STJE0019117 上海玉博生物科技有限公司

Human TNS3 (Tensin 3) Sandwich ELISA Kit Ready-To-Use (STJE0019117)

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产品名称：Human TNS3 (Tensin 3) Sandwich ELISA Kit Ready-To-Use (STJE0019117)
产品型号：STJE0019117
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human TNS3 (Tensin 3) Sandwich ELISA Kit Ready-To-Use (STJE0019117)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.061ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This TNS3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	TNS3
Gene ID:	64759
Uniprot ID:	TENS3_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed at higher levels in tonsil-derived mesenchymal stem cells (MSCs) than in adipose tissue-derived MSCs or bone marrow-derived MSCs. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.
Post Translational Modifications	Phosphorylated on Ser/Thr and Tyr residues. Phosphorylated on Thr-323 in the C2-type tensin domain following EGF stimulation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex. EGF induces tyrosine phosphorylation in a time- and dose-dependent manner. Phosphorylation of the SH2 domain enhances interaction with PEAK1.
Function	May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization. Enhances RHOA activation in the presence of DLC1. Required for growth factor-induced epithelial cell migration.growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation. Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA. Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration. Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1.
Protein Name	Tensin-3 Tensin-Like Sh2 Domain-Containing Protein 1 Tumor Endothelial Marker 6
Database Links	Reactome: R-HSA-8875513
Cellular Localisation	Cell Junction Focal Adhesion Cell Projection Podosome Localizes To Both Focal And Fibrillar Adhesions But Is Mostly Found In Fibrillar Adhesions
Alternative ELISA Names	Tensin-3 ELISA kit Tensin-Like Sh2 Domain-Containing Protein 1 ELISA kit Tumor Endothelial Marker 6 ELISA kit TNS3 ELISA kit TEM6 ELISA kit TENS1 ELISA kit TPP ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human TNS3 (Tensin 3) Sandwich ELISA Kit Ready-To-Use (STJE0019117)