Human TOP2 (Topoisomerase II) Sandwich ELISA Kit (STJE0012734) STJE0012734 上海玉博生物科技有限公司

Human TOP2 (Topoisomerase II) Sandwich ELISA Kit (STJE0012734)

简单介绍

Human TOP2 (Topoisomerase II) Sandwich ELISA Kit (STJE0012734)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.225ng/mL
Detection Limit:	0.625-40ng/mL
Short Description:	This TOP2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	TOP2A
Gene ID:	7153
Uniprot ID:	TOP2A_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung. Also found in high-grade lymphomas, squamous cell lung tumors and seminomas.
Post Translational Modifications	Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation. (Microbial infection) Deubiquitinated by Epstein-Barr virus BPLF1.leading to stabilized SUMOylated TOP2A trapped in cleavage complexes, which halts the DNA damage response to TOP2A-induced double-strand DNA breaks. SUMOylated.
Function	Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. May play a role in regulating the period length of BMAL1 transcriptional oscillation.
Protein Name	Dna Topoisomerase 2-Alpha Dna Topoisomerase Ii - Alpha Isozyme
Database Links	Reactome: R-HSA-1362277 Reactome: R-HSA-4615885
Cellular Localisation	Cytoplasm Nucleus Nucleoplasm Nucleolus
Alternative ELISA Names	Dna Topoisomerase 2-Alpha ELISA kit Dna Topoisomerase Ii - Alpha Isozyme ELISA kit TOP2A ELISA kit TOP2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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