Human TOP3 (Topoisomerase III) Sandwich ELISA Kit (STJE0012738) STJE0012738 上海玉博生物科技有限公司

Human TOP3 (Topoisomerase III) Sandwich ELISA Kit (STJE0012738)

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产品名称：Human TOP3 (Topoisomerase III) Sandwich ELISA Kit (STJE0012738)
产品型号：STJE0012738
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human TOP3 (Topoisomerase III) Sandwich ELISA Kit (STJE0012738)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.053ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This TOP3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	TOP3A
Gene ID:	7156
Uniprot ID:	TOP3A_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	High expression is found in testis, heart, skeletal muscle and pancreas.
Post Translational Modifications
Function	Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. As an essential component of the RMI complex it is involved in chromosome separation and the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity. It is required for mtDNA decatenation and segregation after completion of replication, in a process that does not require BLM, RMI1 and RMI2.
Protein Name	Dna Topoisomerase 3-Alpha Dna Topoisomerase Iii Alpha
Database Links	Reactome: R-HSA-5685938 Reactome: R-HSA-5685942 Reactome: R-HSA-5693554 Reactome: R-HSA-5693568 Reactome: R-HSA-5693579 Reactome: R-HSA-5693607 Reactome: R-HSA-5693616 Reactome: R-HSA-6804756 Reactome: R-HSA-69473 Reactome: R-HSA-912446 Reactome: R-HSA-9701192 Reactome: R-HSA-9704331 Reactome: R-HSA-9704646 Reactome: R-HSA-9709570 Reactome: R-HSA-9709603
Cellular Localisation	Mitochondrion Matrix
Alternative ELISA Names	Dna Topoisomerase 3-Alpha ELISA kit Dna Topoisomerase Iii Alpha ELISA kit TOP3A ELISA kit TOP3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human TOP3 (Topoisomerase III) Sandwich ELISA Kit (STJE0012738)