Anti-CLEC5A antibody (29-188) (STJ23169) STJ23169 上海玉博生物科技有限公司

Anti-CLEC5A antibody (29-188) (STJ23169)

简单介绍

Anti-CLEC5A antibody (29-188) (STJ23169)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CLEC5A (29-188) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CLEC5A
Gene ID:	23601
Uniprot ID:	CLC5A_HUMAN
Immunogen Region:	29-188
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 29-188 of human CLEC5A (NP_037384.1).
Immunogen Sequence:	QIFNKSNDGFTTTRSYGTVS QIFGSSSPSPNGFITTRSYG TVCPKDWEFYQARCFFLSTS ESSWNESRDFCKGKGSTLAI VNTPEKLKFLQDITDAEKYF IGLIYHREEKRWRWINNSVF NGNVTNQNQNFNCATIGLTK TFDAASCDISYRRICEKNAK

Tissue Specificity	Highly expressed in bone marrow with lower levels in synovium, lung and bronchus. Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells.
Post Translational Modifications	N-glycosylated. Contains sialic acid residues.
Function	Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP. This interaction does not result in viral entry, but stimulates pro-inflammatory cytokine release.
Protein Name	C-Type Lectin Domain Family 5 Member A C-Type Lectin Superfamily Member 5 Myeloid Dap12-Associating Lectin 1 Mdl-1
Database Links	Reactome: R-HSA-2172127 Reactome: R-HSA-6798695
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein
Alternative Antibody Names	Anti-C-Type Lectin Domain Family 5 Member A antibody Anti-C-Type Lectin Superfamily Member 5 antibody Anti-Myeloid Dap12-Associating Lectin 1 antibody Anti-Mdl-1 antibody Anti-CLEC5A antibody Anti-CLECSF5 antibody Anti-MDL1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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