Anti-CLIP1 antibody (1228-1427) (STJ114372) STJ114372 上海玉博生物科技有限公司

Anti-CLIP1 antibody (1228-1427) (STJ114372)

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产品名称：Anti-CLIP1 antibody (1228-1427) (STJ114372)
产品型号：STJ114372
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CLIP1 antibody (1228-1427) (STJ114372)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CLIP1 (1228-1427) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CLIP1
Gene ID:	6249
Uniprot ID:	CLIP1_HUMAN
Immunogen Region:	1228-1427
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1228-1427 of human CLIP1 (NP_002947.1).
Immunogen Sequence:	SALLTEKDAELEKLRNEVTV LRGENASAKSLHSVVQTLES DKVKLELKVKNLELQLKENK RQLSSSSGNTDTQADEDERA QESQIDFLNSVIVDLQRKNQ DLKMKVEMMSEAALNGNGDD LNNYDSDDQEKQSKKKPRLF CDICDCFDLHDTEDCPTQAQ MSEDPPHSTHHGSRGEERPY CEICEMFGHWATNCNDDETF

Tissue Specificity	Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease.
Post Translational Modifications	Phosphorylated. Phosphorylation induces conformational changes by increasing the affinity of the N-terminus for C-terminus, resulting in inhibition of its function thus decreasing its binding to microtubules and DCTN1. Exhibits a folded, autoinhibited conformation when phosphorylated and an open conformation when dephosphorylated with increased binding affinity to microtubules and DCTN1. Phosphorylation regulates its recruitment to tyrosinated microtubules and the recruitment of vesicular cargo to microtubules in neurons. Phosphorylation by MTOR may positively regulate CLIP1 association with microtubules.
Function	Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.
Protein Name	Cap-Gly Domain-Containing Linker Protein 1 Cytoplasmic Linker Protein 1 Cytoplasmic Linker Protein 170 Alpha-2 Clip-170 Reed-Sternberg Intermediate Filament-Associated Protein Restin
Database Links	Reactome: R-HSA-141444 Reactome: R-HSA-2467813 Reactome: R-HSA-2500257 Reactome: R-HSA-5626467 Reactome: R-HSA-5663220 Reactome: R-HSA-68877 Reactome: R-HSA-9648025
Cellular Localisation	Cytoplasm Cytoskeleton Cytoplasmic Vesicle Membrane Peripheral Membrane Protein Cytoplasmic Side Cell Projection Ruffle Localizes To Microtubule Plus Ends Localizes Preferentially To The Ends Of Tyrosinated Microtubules Accumulates In Plasma Membrane Regions With Ruffling And Protrusions Associates With The Membranes Of Intermediate Macropinocytic Vesicles
Alternative Antibody Names	Anti-Cap-Gly Domain-Containing Linker Protein 1 antibody Anti-Cytoplasmic Linker Protein 1 antibody Anti-Cytoplasmic Linker Protein 170 Alpha-2 antibody Anti-Clip-170 antibody Anti-Reed-Sternberg Intermediate Filament-Associated Protein antibody Anti-Restin antibody Anti-CLIP1 antibody Anti-CYLN1 antibody Anti-RSN antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CLIP1 antibody (1228-1427) (STJ114372)