Human TRAF3 (TNF Receptor Associated Factor 3) Sandwich ELISA Kit Ready-To-Use (STJE0019174) STJE0019174 上海玉博生物科技有限公司

Human TRAF3 (TNF Receptor Associated Factor 3) Sandwich ELISA Kit Ready-To-Use (STJE0019174)

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产品名称：Human TRAF3 (TNF Receptor Associated Factor 3) Sandwich ELISA Kit Ready-To-Use (STJE0019174)
产品型号：STJE0019174
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human TRAF3 (TNF Receptor Associated Factor 3) Sandwich ELISA Kit Ready-To-Use (STJE0019174)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	29pg/mL
Detection Limit:	78.1-5000pg/mL
Short Description:	This TRAF3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	TRAF3
Gene ID:	7187
Uniprot ID:	TRAF3_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Undergoes 'Lys-48'-linked polyubiquitination, leading to its proteasomal degradation in response to signaling by TNFSF13B, TLR4 or through CD40. 'Lys-48'-linked polyubiquitinated form is deubiquitinated by OTUD7B, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Undergoes 'Lys-63'-linked ubiquitination during early stages of virus infection, and 'Lys-48'-linked ubiquitination during later stages. Undergoes both 'Lys-48'-linked and 'Lys-63'-linked ubiquitination in response to TLR3 and TLR4 signaling. 'Lys-63'-linked ubiquitination can be mediated by TRIM35. Deubiquitinated by OTUB1, OTUB2 and OTUD5. Undergoes 'Lys-63'-linked deubiquitination by MYSM1 to terminate the pattern-recognition receptors/PRRs pathways. Undergoes also 'Lys-29'-linked ubiquitination on Cys-56 and Cys-124 by NEDD4L.leading to increased 'Lys-48'- and 'Lys-63'-linked ubiquitination as well as increased binding to TBK1. TLR4 signals emanating from bacteria containing vesicles trigger 'Lys-33'-linked polyubiquitination that promotes the assembly of the exocyst complex thereby connecting innate immune signaling to the cellular trafficking apparatus. Deubiquitinated by USP25 during viral infection, leading to TRAF3 stabilization and type I interferon production. Ubiquitinated at Lys-329 by the SCF(FBXL2) complex, leading to its degradation by the proteasome. 'Lys-63'-linked ubiquitination by FBXO11 in a NEDD8-dependent manner promotes the amplification of IFN-I signaling. (Microbial infection) Cleaved by enterovirus D68 protease 2A.leading to inhibition of NF-kappa-B or IFN-beta triggered by TRAF3.
Function	Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types. In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome. Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines. Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance. Acts also as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
Protein Name	Tnf Receptor-Associated Factor 3 Cd40 Receptor-Associated Factor 1 Craf1 Cd40-Binding Protein Cd40bp Lmp1-Associated Protein 1 Lap1 Ring-Type E3 Ubiquitin Transferase Traf3
Database Links	Reactome: R-HSA-5602571 Reactome: R-HSA-5668541 Reactome: R-HSA-5676594 Reactome: R-HSA-5689896 Reactome: R-HSA-9013973 Reactome: R-HSA-918233 Reactome: R-HSA-936440 Reactome: R-HSA-936964 Reactome: R-HSA-9692916 Reactome: R-HSA-9705671
Cellular Localisation	Cytoplasm Endosome Mitochondrion Undergoes Endocytosis Together With Tlr4 Upon Lps Signaling Co-Localized To Mitochondria With Trim35
Alternative ELISA Names	Tnf Receptor-Associated Factor 3 ELISA kit Cd40 Receptor-Associated Factor 1 ELISA kit Craf1 ELISA kit Cd40-Binding Protein ELISA kit Cd40bp ELISA kit Lmp1-Associated Protein 1 ELISA kit Lap1 ELISA kit Ring-Type E3 Ubiquitin Transferase Traf3 ELISA kit TRAF3 ELISA kit CAP-1 ELISA kit CRAF1 ELISA kit TRAFAMN ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human TRAF3 (TNF Receptor Associated Factor 3) Sandwich ELISA Kit Ready-To-Use (STJE0019174)