Human TRAM1 (Translocation Associated Membrane Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0019181) STJE0019181 上海玉博生物科技有限公司

Human TRAM1 (Translocation Associated Membrane Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0019181)

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产品名称：Human TRAM1 (Translocation Associated Membrane Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0019181)
产品型号：STJE0019181
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human TRAM1 (Translocation Associated Membrane Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0019181)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.059ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This TRAM1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	TRAM1
Gene ID:	23471
Uniprot ID:	TRAM1_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications	N-glycosylated.
Function	Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel. Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER. May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport. Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane. Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane. Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome. (Microbial infection) In case of cytomegalovirus infection, participates in US2- and US11-mediated ER-to-cytosol retrotranslocation and subsequent degradation of major histocompatibility complex (MHC) class I heavy chains, thereby decreasing the immune detection by cytotoxic T-cells.
Protein Name	Translocating Chain-Associated Membrane Protein 1 Protein Tram1
Database Links	Reactome: R-HSA-1799339
Cellular Localisation	Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein
Alternative ELISA Names	Translocating Chain-Associated Membrane Protein 1 ELISA kit Protein Tram1 ELISA kit TRAM1 ELISA kit TRAM ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human TRAM1 (Translocation Associated Membrane Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0019181)