Human TUBb3 (Tubulin Beta 3) Sandwich ELISA Kit (STJE0012867) STJE0012867 上海玉博生物科技有限公司

Human TUBb3 (Tubulin Beta 3) Sandwich ELISA Kit (STJE0012867)

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产品名称：Human TUBb3 (Tubulin Beta 3) Sandwich ELISA Kit (STJE0012867)
产品型号：STJE0012867
产品展商：ST john's laboratory
产品文档：无相关文档

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Human TUBb3 (Tubulin Beta 3) Sandwich ELISA Kit (STJE0012867)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.116ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This TUBb3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	TUBB3
Gene ID:	10381
Uniprot ID:	TBB3_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues.
Post Translational Modifications	Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group. Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Glutamylation is also involved in cilia motility. Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into cilia and flagella axonemes, which is required for their stability and maintenance. Flagella glycylation controls sperm motility. Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.
Function	Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB3 plays a critical role in proper axon guidance and maintenance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord.
Protein Name	Tubulin Beta-3 Chain Tubulin Beta-4 Chain Tubulin Beta-Iii
Database Links	Reactome: R-HSA-1445148 Reactome: R-HSA-190840 Reactome: R-HSA-190861 Reactome: R-HSA-2132295 Reactome: R-HSA-2467813 Reactome: R-HSA-2500257 Reactome: R-HSA-3371497 Reactome: R-HSA-380320 Reactome: R-HSA-389957 Reactome: R-HSA-389960 Reactome: R-HSA-389977 Reactome: R-HSA-437239 Reactome: R-HSA-5610787 Reactome: R-HSA-5617833 Reactome: R-HSA-5620924 Reactome: R-HSA-5626467 Reactome: R-HSA-5663220 Reactome: R-HSA-6807878 Reactome: R-HSA-6811434 Reactome: R-HSA-6811436 Reactome: R-HSA-68877 Reactome: R-HSA-8852276 Reactome: R-HSA-8955332 Reactome: R-HSA-9609690 Reactome: R-HSA-9609736 Reactome: R-HSA-9619483 Reactome: R-HSA-9646399 Reactome: R-HSA-9648025 Reactome: R-HSA-9668328 Reactome: R-HSA-983189
Cellular Localisation	Cytoplasm Cytoskeleton Cell Projection Growth Cone Lamellipodium Filopodium
Alternative ELISA Names	Tubulin Beta-3 Chain ELISA kit Tubulin Beta-4 Chain ELISA kit Tubulin Beta-Iii ELISA kit TUBB3 ELISA kit TUBB4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human TUBb3 (Tubulin Beta 3) Sandwich ELISA Kit (STJE0012867)