Anti-CNOT7 antibody (90-160) (STJ111494) STJ111494 上海玉博生物科技有限公司

Anti-CNOT7 antibody (90-160) (STJ111494)

简单介绍

Anti-CNOT7 antibody (90-160) (STJ111494)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CNOT7 (90-160) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:200-1:2000 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CNOT7
Gene ID:	29883
Uniprot ID:	CNOT7_HUMAN
Immunogen Region:	90-160
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 90-160 of human CNOT7 (NP_037486.2).
Immunogen Sequence:	PGTSTWQFNFKFNLTEDMYA QDSIELLTTSGIQFKKHEEE GIETQYFAELLMTSGVVLCE GVKWLSFHSGY

Function	Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
Protein Name	Ccr4-Not Transcription Complex Subunit 7 Btg1-Binding Factor 1 Ccr4-Associated Factor 1 Caf-1 Caf1a
Database Links	Reactome: R-HSA-429947 Reactome: R-HSA-6804115
Cellular Localisation	Nucleus Cytoplasm P-Body Cytoplasmic Ribonucleoprotein Granule Nanos2 Promotes Its Localization To P-Body Recruited To Cytoplasmic Ribonucleoprotein Membraneless Compartments By Caprin1 Promoting Deadenylation Of Mrnas
Alternative Antibody Names	Anti-Ccr4-Not Transcription Complex Subunit 7 antibody Anti-Btg1-Binding Factor 1 antibody Anti-Ccr4-Associated Factor 1 antibody Anti-Caf-1 antibody Anti-Caf1a antibody Anti-CNOT7 antibody Anti-CAF1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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