Anti-CNOT8 antibody (1-292) (STJ110361) STJ110361 上海玉博生物科技有限公司

Anti-CNOT8 antibody (1-292) (STJ110361)

简单介绍

Anti-CNOT8 antibody (1-292) (STJ110361)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CNOT8 (1-292) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CNOT8
Gene ID:	9337
Uniprot ID:	CNOT8_HUMAN
Immunogen Region:	1-292
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human CNOT8 (NP_004770.4).
Immunogen Sequence:	MPAALVENSQVICEVWASNL EEEMRKIREIVLSYSYIAMD TEFPGVVVRPIGEFRSSIDY QYQLLRCNVDLLKIIQLGLT FTNEKGEYPSGINTWQFNFK FNLTEDMYSQDSIDLLANSG LQFQKHEEEGIDTLHFAELL MTSGVVLCDNVKWLSFHSGY DFGYMVKLLTDSRLPEEEHE FFHILNLFFPSIYDVKYLMK SCKNLKGGLQEVADQLDLQR IGRQHQAGSDSLLTGMAFF

Function	Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
Protein Name	Ccr4-Not Transcription Complex Subunit 8 Caf1-Like Protein Califp Caf2 Ccr4-Associated Factor 8 Caf1b
Database Links	Reactome: R-HSA-429947 Reactome: R-HSA-6804115
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-Ccr4-Not Transcription Complex Subunit 8 antibody Anti-Caf1-Like Protein antibody Anti-Califp antibody Anti-Caf2 antibody Anti-Ccr4-Associated Factor 8 antibody Anti-Caf1b antibody Anti-CNOT8 antibody Anti-CALIF antibody Anti-POP2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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