Human Tyk2 (Tyrosine Kinase 2) Sandwich ELISA Kit Ready-To-Use (STJE0019262) STJE0019262 上海玉博生物科技有限公司

Human Tyk2 (Tyrosine Kinase 2) Sandwich ELISA Kit Ready-To-Use (STJE0019262)

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产品名称：Human Tyk2 (Tyrosine Kinase 2) Sandwich ELISA Kit Ready-To-Use (STJE0019262)
产品型号：STJE0019262
产品展商：ST john's laboratory
产品文档：无相关文档

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Human Tyk2 (Tyrosine Kinase 2) Sandwich ELISA Kit Ready-To-Use (STJE0019262)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.097ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This Tyk2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	TYK2
Gene ID:	7297
Uniprot ID:	TYK2_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
Post Translational Modifications	Phosphorylated. Phosphorylation by JAK1 at Tyr-1054 and Tyr-1055 induces kinase activation.
Function	Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity. Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling. Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6. The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2. In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members. In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes. Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling.
Protein Name	Non-Receptor Tyrosine-Protein Kinase Tyk2
Database Links	Reactome: R-HSA-1059683 Reactome: R-HSA-110056 Reactome: R-HSA-112411 Reactome: R-HSA-449836 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-6788467 Reactome: R-HSA-8854691 Reactome: R-HSA-8984722 Reactome: R-HSA-9020591 Reactome: R-HSA-9020933 Reactome: R-HSA-9020956 Reactome: R-HSA-909733 Reactome: R-HSA-912694 Reactome: R-HSA-9674555 Reactome: R-HSA-9679191 Reactome: R-HSA-9705462 Reactome: R-HSA-9705671
Cellular Localisation
Alternative ELISA Names	Non-Receptor Tyrosine-Protein Kinase Tyk2 ELISA kit TYK2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human Tyk2 (Tyrosine Kinase 2) Sandwich ELISA Kit Ready-To-Use (STJE0019262)