Human UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1) Sandwich ELISA Kit Ready-To-Use (STJE0019311) STJE0019311 上海玉博生物科技有限公司

Human UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1) Sandwich ELISA Kit Ready-To-Use (STJE0019311)

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产品名称：Human UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1) Sandwich ELISA Kit Ready-To-Use (STJE0019311)
产品型号：STJE0019311
产品展商：ST john's laboratory
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简单介绍

Human UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1) Sandwich ELISA Kit Ready-To-Use (STJE0019311)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.51ng/mL
Detection Limit:	1.56-100ng/mL
Short Description:	This UGT1A1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	UGT1A1
Gene ID:	54658
Uniprot ID:	UD11_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Isoform 1: Expressed in liver, colon and small intestine. Not expressed in kidney, esophagus and skin. Isoform 2: Expressed in liver, colon, small intestine and kidney. Not expressed in esophagus and skin.
Post Translational Modifications
Function	Isoform 1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol. Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates. Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan. Isoform 2: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
Protein Name	Udp-Glucuronosyltransferase 1a1 Ugt1a1 Bilirubin-Specific Udpgt Isozyme 1 Hug-Br1 Udp-Glucuronosyltransferase 1-1 Udpgt 1-1 Ugt1*1 Ugt1-01 Ugt1.1 Udp-Glucuronosyltransferase 1a Isoform 1
Database Links	Reactome: R-HSA-156588 Reactome: R-HSA-189483 Reactome: R-HSA-5579002 Reactome: R-HSA-9749641 Reactome: R-HSA-9753281
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Membrane Protein Cytoplasm Perinuclear Region
Alternative ELISA Names	Udp-Glucuronosyltransferase 1a1 ELISA kit Ugt1a1 ELISA kit Bilirubin-Specific Udpgt Isozyme 1 ELISA kit Hug-Br1 ELISA kit Udp-Glucuronosyltransferase 1-1 ELISA kit Udpgt 1-1 ELISA kit Ugt1*1 ELISA kit Ugt1-01 ELISA kit Ugt1.1 ELISA kit Udp-Glucuronosyltransferase 1a Isoform 1 ELISA kit UGT1A1 ELISA kit GNT1 ELISA kit UGT1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human UGT1A1 (UDP Glucuronosyltransferase 1 Family, Polypeptide A1) Sandwich ELISA Kit Ready-To-Use (STJE0019311)